{"id":"W2078673393","doi":"10.1371/journal.pbio.0030041","title":"SIRT1 Regulates HIV Transcription via Tat Deacetylation","year":2005,"lang":"en","type":"article","venue":"PLoS Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"National Institutes of Health; Gladstone Institutes; Division of Chemistry; Ellison Medical Foundation","keywords":"Transactivation; Biology; Coactivator; Sirtuin 1; Acetylation; Gene knockdown; Histone deacetylase; P300-CBP Transcription Factors; Transcription (linguistics); PCAF; Histone; Sirtuin; Cell biology; HDAC4; Transcription factor; Molecular biology; Histone Acetyltransferases; Biochemistry; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446369,0.0003165642,0.0002020603,0.0001790235,0.000296948,0.0005050816,0.0002687118,0.000265883,0.001600422],"category_scores_gemma":[0.000165535,0.0001903367,0.0003129707,0.0001196702,0.0002423902,0.0002152932,0.000216675,0.0005298048,0.0007087006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713704,"about_ca_system_score_gemma":0.0001895961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005968633,"about_ca_topic_score_gemma":0.001346868,"domain_scores_codex":[0.999881,0.00002117575,0.000006493538,0.00002926361,0.00003301338,0.00002910841],"domain_scores_gemma":[0.9999219,0.00001076668,0.00002490476,0.000009917954,0.0000135035,0.00001904482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001891061,0.00002604951,0.001007168,0.00008712833,0.00001709601,0.0001299228,0.00004346231,0.0001910264,0.9888965,0.0007973732,0.0004133575,0.008201804],"study_design_scores_gemma":[0.00004513705,0.0001781443,0.01250768,0.0000139788,0.00004042071,0.0004555655,0.00004857266,0.002184127,0.965133,0.0005333934,0.01884415,0.00001588408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623523,0.0176514,0.008802594,0.0008010138,0.000292567,0.00004420329,0.0007902195,0.0004586106,0.008807297],"genre_scores_gemma":[0.9881064,0.003686191,0.002657512,0.0001235404,0.00005017507,0.00001660191,0.0006354391,0.00002732137,0.004696873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600422,"threshold_uncertainty_score":0.005353928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880259319956191,"score_gpt":0.2496259835137341,"score_spread":0.2308233903141722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}