{"id":"W2078673393","doi":"10.1371/journal.pbio.0030041","title":"SIRT1 Regulates HIV Transcription via Tat Deacetylation","year":2005,"lang":"en","type":"article","venue":"PLoS Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"National Institutes of Health; Gladstone Institutes; Division of Chemistry; Ellison Medical Foundation","keywords":"Transactivation; Biology; Coactivator; Sirtuin 1; Acetylation; Gene knockdown; Histone deacetylase; P300-CBP Transcription Factors; Transcription (linguistics); PCAF; Histone; Sirtuin; Cell biology; HDAC4; Transcription factor; Molecular biology; Histone Acetyltransferases; Biochemistry; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001090831,0.0001356722,0.0001895479,0.00009676564,0.000136183,0.000005942617,0.0001152207,0.0002562172,0.001799775],"category_scores_gemma":[0.00003688098,0.0001068604,0.00006043696,0.00009268095,0.0001711571,0.00007497887,0.00002181268,0.000168766,0.009062571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006208004,"about_ca_system_score_gemma":0.0000272141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003060039,"about_ca_topic_score_gemma":0.00006688131,"domain_scores_codex":[0.9988973,0.0002232059,0.0001917564,0.0002729608,0.00002008558,0.0003946568],"domain_scores_gemma":[0.9995982,0.00007783325,0.00004411542,0.0001893552,0.00005922984,0.00003124377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336985,0.0002700505,0.003865124,0.000005715625,0.0001893496,0.000001683539,0.0002050809,0.000004984868,0.9533667,0.0007559597,0.002114152,0.03908748],"study_design_scores_gemma":[0.002558381,0.0005708721,0.0116609,0.00001310835,0.00006514997,0.00005756233,0.00004593893,0.00008946686,0.7756303,0.0007856752,0.2082918,0.0002308118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890367,0.004156422,0.0009756915,0.002855579,0.0001703444,0.0003233787,0.00009250054,0.0001471633,0.002242235],"genre_scores_gemma":[0.9945548,0.0001431858,0.0003487201,0.0001251855,0.00007356425,0.00004973615,0.001426018,0.00001113438,0.003267708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2061777,"threshold_uncertainty_score":0.9991127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880259319956191,"score_gpt":0.2496259835137341,"score_spread":0.2308233903141722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}