{"id":"W2078748900","doi":"10.1002/mabi.201000402","title":"Impact of Lipid Substitution on Assembly and Delivery of siRNA by Cationic Polymers","year":2011,"lang":"en","type":"article","venue":"Macromolecular Bioscience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polymer; Chemistry; Cationic polymerization; Gene silencing; Biophysics; Intracellular; Small interfering RNA; Polymer chemistry; Biochemistry; Combinatorial chemistry; Transfection; Organic chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002482407,0.0004644135,0.0001906795,0.0001687699,0.0001189254,0.0003525006,0.0001397646,0.0002108286,0.0006674906],"category_scores_gemma":[0.0004241111,0.0002030003,0.0001439216,0.0001562804,0.0001881604,0.0002530027,0.0001940675,0.0002688814,0.0002648687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913457,"about_ca_system_score_gemma":0.0001785988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002969237,"about_ca_topic_score_gemma":0.0003181539,"domain_scores_codex":[0.9998329,0.00004624209,0.00001854149,0.00003833742,0.00003326236,0.00003066646],"domain_scores_gemma":[0.9997829,0.00008010246,0.00005582339,0.00001486863,0.00002978372,0.0000366483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110074,0.00001374019,0.00007571829,0.00002574422,0.000005522454,0.00004704582,0.00001296165,0.0001326278,0.9986233,0.00002559408,0.000006707127,0.000921105],"study_design_scores_gemma":[0.000005269123,0.0001576353,0.0003312866,0.000001896962,0.00001147426,0.00004154217,0.000003029366,0.0002312037,0.9988753,0.000006276764,0.0003324723,0.000002618445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960309,0.0005850514,0.002361066,0.00002837821,0.000008743033,0.00003310195,0.00006261838,0.00005093897,0.0008392824],"genre_scores_gemma":[0.9959915,0.000578995,0.002078751,0.00003137363,0.000004088037,0.00003152395,0.0001207714,0.00003967633,0.001123491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006674906,"threshold_uncertainty_score":0.002232969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449551844643004,"score_gpt":0.24956264613366,"score_spread":0.2350671276872299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}