{"id":"W2078748900","doi":"10.1002/mabi.201000402","title":"Impact of Lipid Substitution on Assembly and Delivery of siRNA by Cationic Polymers","year":2011,"lang":"en","type":"article","venue":"Macromolecular Bioscience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polymer; Chemistry; Cationic polymerization; Gene silencing; Biophysics; Intracellular; Small interfering RNA; Polymer chemistry; Biochemistry; Combinatorial chemistry; Transfection; Organic chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066325,0.0001150999,0.000112633,0.00006292159,0.00004284435,0.000008119183,0.0002131527,0.00007850918,0.00002236977],"category_scores_gemma":[0.00003355464,0.0001013142,0.00008907013,0.0001418638,0.0002827313,0.000008004972,0.00006379376,0.00003875608,0.000002908482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001164465,"about_ca_system_score_gemma":0.0001031405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410421,"about_ca_topic_score_gemma":0.000006752919,"domain_scores_codex":[0.9992085,0.00003406187,0.00017349,0.0002826262,0.0001345332,0.0001668372],"domain_scores_gemma":[0.9994605,0.00000425071,0.0001183329,0.000261312,0.00009106116,0.00006452447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006329332,0.00008340531,0.003587581,0.000006183451,0.00002609934,0.000001372641,0.00004607172,0.000006155867,0.9949693,0.00006692598,0.0001145436,0.001029064],"study_design_scores_gemma":[0.0001688702,0.001201485,0.01763059,0.00001812163,0.00001203653,0.000009580529,0.0000155525,0.00006026787,0.9807073,0.0000134139,0.00005211016,0.0001106226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997356,0.0004802609,0.001007377,0.000007377546,0.0000592059,0.00007818906,0.0000374531,0.000003519461,0.0009706286],"genre_scores_gemma":[0.9994125,0.0002886782,0.0001475067,0.00004789225,0.00001137776,0.000002917893,0.00002132007,0.000006381449,0.00006138191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01426195,"threshold_uncertainty_score":0.4131473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449551844643004,"score_gpt":0.24956264613366,"score_spread":0.2350671276872299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}