{"id":"W2078756676","doi":"10.1016/j.exer.2005.11.002","title":"Functional analysis of the glaucoma-causing TIGR/myocilin protein: Integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion","year":2006,"lang":"en","type":"article","venue":"Experimental Eye Research","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Glaucoma Foundation; Fonds de Recherche du Québec - Santé; Fondation des Maladies de l'Oeil; Glaucoma Research Foundation","keywords":"Myocilin; Biology; Mutant; Molecular biology; Secretion; Trabecular meshwork; Extracellular; Mutation; Genetics; Gene; Glaucoma; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007066133,0.0001412569,0.0003709036,0.0003892433,0.0002604224,0.00001563783,0.00007354542,0.0001722568,0.0001382641],"category_scores_gemma":[0.00007053874,0.0001026311,0.0001881619,0.00056762,0.00111295,0.00005951354,0.0001253454,0.0003461937,7.485457e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000794513,"about_ca_system_score_gemma":0.0001156931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008488817,"about_ca_topic_score_gemma":0.00006661219,"domain_scores_codex":[0.9981205,0.0002537273,0.0003696083,0.0003406535,0.0006246258,0.0002908442],"domain_scores_gemma":[0.9991798,0.0001554388,0.0001244104,0.0002296474,0.0002235729,0.00008712635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009930861,0.0004697654,0.07354964,0.0001687968,0.0001715728,0.00001433871,0.0007058023,2.785087e-7,0.9220157,0.001466028,0.0002759322,0.0001690362],"study_design_scores_gemma":[0.002029918,0.0008516551,0.375181,0.000175778,0.0002510179,0.00005415206,0.004098383,0.001687663,0.6145105,0.0007276526,0.0003065222,0.0001257526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950011,0.002473718,0.0004857423,0.0009504899,0.0000458757,0.0008530481,0.00003109393,0.000008238523,0.0001506373],"genre_scores_gemma":[0.998454,0.00003111155,0.0004934166,0.00001099414,0.00006669806,0.00007642727,0.000089505,0.00001355296,0.000764271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3075052,"threshold_uncertainty_score":0.4185174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04334706009140632,"score_gpt":0.3526285320279997,"score_spread":0.3092814719365934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}