{"id":"W2078762484","doi":"10.1371/journal.pone.0080532","title":"β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Center for Advancing Translational Sciences; Howard Hughes Medical Institute","keywords":"Arrestin; Myosin light-chain kinase; Cell biology; Phosphorylation; Motility; Dephosphorylation; Myosin; Biology; G protein-coupled receptor; Signal transduction; Chemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156422,0.00008155216,0.0001050401,0.00003108125,0.00004273908,0.00001884015,0.00003046211,0.0001202291,0.00009473399],"category_scores_gemma":[0.00007627808,0.00007924576,0.00002058794,0.00005024663,0.00001608892,0.0000119462,0.00001289036,0.00004136641,0.000008336796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007459535,"about_ca_system_score_gemma":0.00001412832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006387561,"about_ca_topic_score_gemma":0.0000155641,"domain_scores_codex":[0.9993974,0.00003858933,0.0001808313,0.0001689237,0.0001221828,0.00009205642],"domain_scores_gemma":[0.9995602,0.00001382699,0.0001413927,0.0001036593,0.0001423863,0.00003853317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002482325,0.0001744496,0.001469617,0.00003790794,0.00002170833,4.578306e-8,0.00007902948,0.000009543695,0.9975293,0.00002052088,0.00007114442,0.0005619166],"study_design_scores_gemma":[0.0002826148,0.0001989282,0.006310794,0.0000417002,0.00002463696,3.273301e-7,0.00003396878,0.005117743,0.9876686,0.0001600723,0.00007289999,0.00008775036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975778,0.000384912,0.001278853,0.0002084959,0.00002749855,0.0003718504,0.000003634809,0.00001159434,0.0001353571],"genre_scores_gemma":[0.9970736,0.0001182528,0.002179841,0.00002103705,0.00008870785,0.00003134048,0.0001926969,0.00001203507,0.0002824945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009860728,"threshold_uncertainty_score":0.3231548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104414746560684,"score_gpt":0.1815058556460166,"score_spread":0.1710643809899482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}