{"id":"W2078767008","doi":"10.1097/mco.0b013e32835ad2ee","title":"The nutritional burden of methylation reactions","year":2012,"lang":"en","type":"review","venue":"Current Opinion in Clinical Nutrition & Metabolic Care","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Transmethylation; Methionine; Betaine; Choline; Methylation; Creatine; Limiting; Biochemistry; Chemistry; Homocysteine; Methyl group; Methyltransferase; Hyperhomocysteinemia; Amino acid; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001654257,0.0003651078,0.002042907,0.0005547052,0.0001533484,0.00003552547,0.0002971126,0.0006113039,0.0001264706],"category_scores_gemma":[0.0009546857,0.0002534699,0.001586573,0.001090854,0.0003181843,0.0001347141,0.0001251645,0.001833457,0.0001175966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493197,"about_ca_system_score_gemma":0.0005348295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003020215,"about_ca_topic_score_gemma":0.000003049878,"domain_scores_codex":[0.9945321,0.0009612596,0.002709752,0.0005050912,0.0008496796,0.0004421112],"domain_scores_gemma":[0.9954332,0.002172968,0.0007039959,0.0006916653,0.0007243892,0.000273746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006826704,0.0008488479,0.00005794454,0.03620562,0.0001382358,4.579351e-7,0.00004252986,1.26656e-7,7.134323e-7,0.001386253,0.002077144,0.9591739],"study_design_scores_gemma":[0.001697252,0.0001140728,0.0004198386,0.0246704,0.0006767865,0.00002427432,0.0001836435,0.000006235006,0.000001324873,0.0001556707,0.971844,0.000206545],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002107922,0.9910806,0.00001696435,0.0002743051,0.005823321,0.002194905,0.000372266,0.00003252578,0.0001839734],"genre_scores_gemma":[0.0001351242,0.9892882,0.0001435224,0.00000423527,0.006522087,0.0006663707,0.003127196,0.00004661737,0.00006667096],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9697668,"threshold_uncertainty_score":0.9999918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3307338708530107,"score_gpt":0.546031034769986,"score_spread":0.2152971639169753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}