{"id":"W2078775366","doi":"10.1016/j.bbrc.2011.08.103","title":"Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons","year":2011,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Calgary; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Orexigenic; Endocrinology; Internal medicine; Neuropeptide; Biology; Lipotoxicity; Neuropeptide Y receptor; AMPK; Energy homeostasis; Hypothalamus; Chemistry; Cell biology; Insulin resistance; Insulin; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003279929,0.0001638575,0.0001967663,0.00008890252,0.0004012954,0.00004672214,0.0008302653,0.00007288581,0.00001063143],"category_scores_gemma":[0.0006321704,0.0001116216,0.00008285625,0.0004716451,0.002494751,0.00009394805,0.00092139,0.0005656266,0.00001699537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001288737,"about_ca_system_score_gemma":0.00006529945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005251675,"about_ca_topic_score_gemma":0.000001826492,"domain_scores_codex":[0.9978676,0.0006319394,0.0003045094,0.0004267099,0.0003916065,0.000377679],"domain_scores_gemma":[0.9975474,0.0007795736,0.00009200159,0.001258303,0.00009591605,0.000226729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003776715,0.0001277818,0.0001097176,0.00001921613,0.000004928482,0.000008299628,0.0003593689,2.551681e-7,0.9799288,0.01856132,0.00003916228,0.0008034016],"study_design_scores_gemma":[0.0002452596,0.00009541,0.004048778,0.00004767838,0.00001332096,0.00003651806,0.00008345168,0.0003130091,0.9926339,0.00193885,0.0004164733,0.0001273275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959824,0.001950048,0.00001826399,0.0008814273,0.00002500977,0.0003682744,0.0000437497,0.00002737596,0.0007034627],"genre_scores_gemma":[0.9973132,0.001906202,0.0004443001,0.0001343777,0.00002542179,0.00006236273,0.000003813064,0.00002251251,0.0000877905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01662247,"threshold_uncertainty_score":0.9192016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1541804242074878,"score_gpt":0.3394697121811621,"score_spread":0.1852892879736743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}