{"id":"W2078818999","doi":"10.1016/j.bbadis.2006.03.006","title":"Transgenic mouse models of amyotrophic lateral sclerosis","year":2006,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Genetically modified mouse; Transgene; Mutant; Missense mutation; Biology; Motor neuron; Cell biology; Pathogenesis; Neurofilament; Superoxide dismutase; Mutation; Genetics; Gene; Neuroscience; Disease; Biochemistry; Medicine; Immunology; Pathology; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0002829328,0.001368645,0.00419765,0.0008520237,0.00009227412,0.00006907511,0.001197869,0.0006635899,0.0000939614],"category_scores_gemma":[0.00008512254,0.001138128,0.004149932,0.001282707,0.0007352041,0.000240205,0.0003985903,0.000920573,0.00003818214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254401,"about_ca_system_score_gemma":0.001409127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001861994,"about_ca_topic_score_gemma":0.000001943681,"domain_scores_codex":[0.9927738,0.0007057738,0.002072832,0.001505976,0.001882442,0.001059211],"domain_scores_gemma":[0.9948971,0.0001241264,0.00108864,0.002411966,0.0004348962,0.001043294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002239385,0.007221847,0.000003993653,0.09377873,0.005883654,0.0001586494,0.0001423126,0.0001084593,0.8370398,0.0007176751,0.001482682,0.05122287],"study_design_scores_gemma":[0.01946341,0.006358813,0.006306218,0.1525767,0.07423194,0.0000450132,0.00003155376,0.001728466,0.7042024,0.002167127,0.02107851,0.01180986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5053678,0.4889674,0.00006063765,0.0005367292,0.00007160891,0.002585775,0.002125547,0.0001238534,0.0001606697],"genre_scores_gemma":[0.3826913,0.6147937,0.0004020459,0.0001071326,0.0001141898,0.0002050628,0.00124336,0.0002877626,0.0001555127],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1328373,"threshold_uncertainty_score":0.9999064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0606833630618201,"score_gpt":0.3224631155531892,"score_spread":0.2617797524913691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}