{"id":"W2078818999","doi":"10.1016/j.bbadis.2006.03.006","title":"Transgenic mouse models of amyotrophic lateral sclerosis","year":2006,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Genetically modified mouse; Transgene; Mutant; Missense mutation; Biology; Motor neuron; Cell biology; Pathogenesis; Neurofilament; Superoxide dismutase; Mutation; Genetics; Gene; Neuroscience; Disease; Biochemistry; Medicine; Immunology; Pathology; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006522009,0.00150241,0.00199395,0.001730514,0.0002413368,0.0007546688,0.001826654,0.00124234,0.001753694],"category_scores_gemma":[0.0003361821,0.0003150041,0.0003714993,0.001321182,0.0005807741,0.0009161915,0.0004203109,0.001888702,0.001732519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006301453,"about_ca_system_score_gemma":0.0005254163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007765287,"about_ca_topic_score_gemma":0.001693802,"domain_scores_codex":[0.9998367,0.00002088182,0.00001960923,0.00002948692,0.00007406185,0.00001919955],"domain_scores_gemma":[0.9998386,0.00004731621,0.00004225914,0.000008757713,0.00004175967,0.00002132036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004310888,0.0003789863,0.0004438466,0.01314637,0.0001947943,0.00142741,0.00009436441,0.0005357906,0.06730324,0.007079539,0.04507255,0.8638919],"study_design_scores_gemma":[0.0001264283,0.0002294266,0.001207039,0.001499652,0.0003397859,0.003090552,0.00005316944,0.0001399582,0.01006616,0.00282405,0.9803797,0.00004408137],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001016513,0.9950131,0.0009994842,0.0003184773,0.0003200499,0.00001951096,0.00007636016,0.00006485103,0.002171705],"genre_scores_gemma":[0.003120035,0.9939429,0.0007679639,0.0002655984,0.0001196384,0.00002979057,0.0001705279,0.000004759395,0.001578789],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00199395,"threshold_uncertainty_score":0.005866647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0606833630618201,"score_gpt":0.3224631155531892,"score_spread":0.2617797524913691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}