{"id":"W2078843727","doi":"10.1016/j.ejmech.2012.04.002","title":"Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Chemistry; Cathepsin; Biochemistry; Enzyme; Papain; Cathepsin L; Non-competitive inhibition; Cysteine Proteinase Inhibitors; Cysteine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00226508,0.0001038156,0.0001735679,0.00002793379,0.00002310187,0.000003392356,0.00008775295,0.00004290526,0.00001633845],"category_scores_gemma":[0.0003762784,0.00008281125,0.00005562217,0.00003063059,0.0001347804,0.000008642941,0.00006395448,0.00009932396,5.006597e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008458113,"about_ca_system_score_gemma":0.00007507748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000187514,"about_ca_topic_score_gemma":7.405407e-8,"domain_scores_codex":[0.9988253,0.0001671173,0.0003728488,0.00009536223,0.0004199692,0.0001194562],"domain_scores_gemma":[0.9990236,0.00001079557,0.0003879673,0.0001244892,0.0003115731,0.0001415339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007554129,0.00006409557,0.0004776261,0.00008684194,0.00005367147,0.00000505071,0.0002141927,0.000002231266,0.9906381,0.000004857566,0.0001159542,0.008261794],"study_design_scores_gemma":[0.0007827581,0.0004196675,0.001058062,0.0002463582,0.0002184474,0.0007583773,0.0004532541,0.000008856201,0.9955303,0.00005041563,0.0003971862,0.00007632067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857298,0.01253159,0.00008819827,0.0000902674,0.0001232111,0.00005200699,0.000003216894,0.000001186873,0.001380513],"genre_scores_gemma":[0.9986304,0.0005340521,0.000155543,0.00002442848,0.0006159657,5.11122e-7,0.00000270943,0.00001306646,0.00002331902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01290059,"threshold_uncertainty_score":0.3376945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713767816392532,"score_gpt":0.2568023290388803,"score_spread":0.239664650874955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}