{"id":"W2078844183","doi":"10.1128/jvi.06728-11","title":"Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Epitope; Biology; Human leukocyte antigen; Allele; Genetics; ELISPOT; HLA-B Antigens; HLA-DRB1; CTL*; Virology; Immune system; Immunology; Antigen; T cell; Gene; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004636656,0.0001012771,0.0004318849,0.00022196,0.00003702862,0.000001673253,0.00009058377,0.0001718666,0.000176914],"category_scores_gemma":[0.0001809864,0.00006663181,0.0001679406,0.00005996219,0.0001939014,0.00008237942,0.00002167979,0.0002776465,0.00005465624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004092758,"about_ca_system_score_gemma":0.00007136447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004996479,"about_ca_topic_score_gemma":0.000001405603,"domain_scores_codex":[0.9988611,0.0003305808,0.0004281134,0.00006544194,0.000043787,0.0002710063],"domain_scores_gemma":[0.998862,0.0004088502,0.0004551027,0.0001269108,0.00009729181,0.00004984192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003046141,0.0005878849,0.09376188,0.000008506968,0.000732259,0.00001143403,0.0001885547,0.00001800231,0.8972331,0.0002651949,0.0009638912,0.003183193],"study_design_scores_gemma":[0.006562706,0.009648178,0.909163,0.00003535419,0.0001353668,0.0005741291,0.00006571683,0.000002848107,0.07270163,0.0001538431,0.0008889326,0.00006831078],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917784,0.007309874,0.00008055005,0.0001511297,0.0002204975,0.00009108798,0.00007543516,0.000002748438,0.0002902909],"genre_scores_gemma":[0.9991534,0.0007000521,0.00003072483,0.00001584059,0.00003941747,0.000001759734,0.00001014881,0.000006281874,0.00004234885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8245314,"threshold_uncertainty_score":0.2717166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400347371810227,"score_gpt":0.2724280692977648,"score_spread":0.2584245955796625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}