{"id":"W2078859290","doi":"10.1128/jvi.77.9.5178-5191.2003","title":"Characterization of the Minimal DNA Binding Domain of the Human Papillomavirus E1 Helicase: Fluorescence Anisotropy Studies and Characterization of a Dimerization-Defective Mutant Protein","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Biology; Helicase; DNA; Replication protein A; DNA replication; Bovine papillomavirus; Molecular biology; DNA-binding domain; Binding domain; SeqA protein domain; DNA-binding protein; HMG-box; Biochemistry; Biophysics; Control of chromosome duplication; Binding site; Gene; Genome; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004419312,0.0001015515,0.0004436295,0.0001186832,0.00009732792,0.000004398666,0.0001158608,0.000079866,0.00007536387],"category_scores_gemma":[0.0003380643,0.00005714766,0.0001036559,0.0003324935,0.0004280085,0.00007874018,0.00006468863,0.0002159515,2.36331e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004907394,"about_ca_system_score_gemma":0.0001239835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004942776,"about_ca_topic_score_gemma":0.000004002855,"domain_scores_codex":[0.9984702,0.0003474611,0.0005839477,0.0001137677,0.0003452111,0.0001393858],"domain_scores_gemma":[0.9984305,0.00006377223,0.0008492147,0.0001613232,0.0004493219,0.00004589146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004561625,0.000124037,0.0231542,0.0001923109,0.0001151882,0.000004101108,0.001025763,3.480613e-7,0.9734877,0.0008143093,7.000687e-7,0.0006251453],"study_design_scores_gemma":[0.0008922773,0.00070733,0.4292664,0.0001111491,0.00006372779,0.00005108839,0.000155036,0.000005962684,0.5684931,0.0001837809,0.00003879869,0.00003136924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986306,0.0001249886,0.0001386131,0.0005093663,0.00008614863,0.0004485118,0.00002008208,0.000001814904,0.00003983905],"genre_scores_gemma":[0.9995195,0.0002322848,0.00008730988,0.00005733041,0.00006018845,0.000007940867,0.00000286059,0.00001066319,0.00002195805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4061122,"threshold_uncertainty_score":0.2330414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574279905183832,"score_gpt":0.3163303325733042,"score_spread":0.2905875335214659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}