{"id":"W2078859290","doi":"10.1128/jvi.77.9.5178-5191.2003","title":"Characterization of the Minimal DNA Binding Domain of the Human Papillomavirus E1 Helicase: Fluorescence Anisotropy Studies and Characterization of a Dimerization-Defective Mutant Protein","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Biology; Helicase; DNA; Replication protein A; DNA replication; Bovine papillomavirus; Molecular biology; DNA-binding domain; Binding domain; SeqA protein domain; DNA-binding protein; HMG-box; Biochemistry; Biophysics; Control of chromosome duplication; Binding site; Gene; Genome; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341472,0.0003910383,0.0003192161,0.0001565465,0.0001844207,0.0002751547,0.0002961566,0.0003520971,0.0005291523],"category_scores_gemma":[0.0003985326,0.0001635091,0.0002753807,0.000198706,0.0002140642,0.000157781,0.0001458004,0.0005091465,0.000348925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005062408,"about_ca_system_score_gemma":0.0002514245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167014,"about_ca_topic_score_gemma":0.000960675,"domain_scores_codex":[0.9997955,0.00004378333,0.00002653092,0.00004030895,0.00006194091,0.00003188633],"domain_scores_gemma":[0.9997249,0.00007876004,0.00006399446,0.00003524054,0.00004677204,0.00005036491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002655715,0.00002055343,0.0001397834,0.00001218197,0.000003103207,0.00001707695,0.00001034892,0.00008273991,0.9993674,0.00004744584,0.000008512528,0.0002643025],"study_design_scores_gemma":[0.000006112899,0.00005189883,0.00178553,0.000003218496,0.000007045593,0.0002176854,0.00001646521,0.001245896,0.9952984,0.00002235626,0.00134086,0.000004422647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992389,0.0005187447,0.006210175,0.00008448843,0.000009946036,0.00002523842,0.0004031846,0.00002843518,0.0003307401],"genre_scores_gemma":[0.9929826,0.0002656322,0.004848987,0.00003954228,0.000004326589,0.00002866687,0.00105971,0.00002810988,0.0007422633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167014,"threshold_uncertainty_score":0.003673017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574279905183832,"score_gpt":0.3163303325733042,"score_spread":0.2905875335214659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}