{"id":"W2078901418","doi":"10.1038/sj.gt.3302486","title":"Combined CD4+ Th1 effect and lymphotactin transgene expression enhance CD8+ Tc1 tumor localization and therapy","year":2005,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Transgene; CD8; Biology; Cytotoxic T cell; Adoptive cell transfer; Genetic enhancement; Ovalbumin; Cancer research; T cell; T-cell receptor; Immunotherapy; Molecular biology; Immunology; Cell therapy; Cell; Immune system; In vitro; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004216152,0.0003483536,0.0004308062,0.0001161162,0.0004015002,0.00004117907,0.0001592926,0.0002177624,0.0004683692],"category_scores_gemma":[0.00001497478,0.0002680561,0.00008552027,0.0001302423,0.0002353056,0.000184465,0.00002405681,0.0001714363,0.00005474513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002673787,"about_ca_system_score_gemma":0.0000416501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003781401,"about_ca_topic_score_gemma":0.000002538257,"domain_scores_codex":[0.9981617,0.0006351033,0.0003336005,0.0004196112,0.00005600955,0.0003939283],"domain_scores_gemma":[0.9992111,0.0002307354,0.0001342915,0.0003515299,0.00004223643,0.00003007402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006547365,0.0001244602,0.0005479348,0.000007384545,0.0001202932,0.000001525702,0.000966445,0.000007252773,0.7920755,0.000009571042,0.000210532,0.1993818],"study_design_scores_gemma":[0.007288258,0.001376884,0.004135852,0.0000384613,0.000009723369,0.00006965466,0.00003835345,0.00001862132,0.9197391,0.00003363552,0.06695736,0.0002941565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.878446,0.1196075,0.0007111789,0.0002705082,0.000255116,0.0005295534,0.000009618591,0.0001061681,0.00006438493],"genre_scores_gemma":[0.9546927,0.04297271,0.0001258665,0.001044481,0.00005692399,0.00007165664,0.00005278278,0.00004824661,0.0009346979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1990876,"threshold_uncertainty_score":0.9999772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007303783084616129,"score_gpt":0.2399381580456141,"score_spread":0.232634374960998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}