{"id":"W2078901618","doi":"10.1074/jbc.m401796200","title":"Mutation of Tyrosine in the Conserved NPXXY Sequence Leads to Constitutive Phosphorylation and Internalization, but Not Signaling, of the Human B2 Bradykinin Receptor","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"G protein-coupled receptor; Internalization; Receptor; Phosphorylation; Biology; Molecular biology; Transmembrane domain; Mutant; Transmembrane protein; Bradykinin receptor; Cell biology; Biochemistry; Bradykinin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004506823,0.0000920048,0.0001706891,0.00001555982,0.00004070836,0.00001048528,0.0002125544,0.0001314394,0.00003143847],"category_scores_gemma":[0.0003394144,0.00005299974,0.0000779555,0.0000968553,0.0001936853,0.000005439874,0.00004279345,0.000124078,1.50215e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002119028,"about_ca_system_score_gemma":0.00007116544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000022827,"about_ca_topic_score_gemma":0.000003245634,"domain_scores_codex":[0.9991456,0.00006843972,0.0004449103,0.0001206332,0.0001356278,0.00008478683],"domain_scores_gemma":[0.999193,0.00003426885,0.0004323957,0.000096895,0.0002102628,0.0000331773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009550572,0.00004462399,0.004419095,0.00001737495,0.00001476529,0.000001921722,0.0001530919,0.0005758366,0.9943686,0.0002145278,0.00001434161,0.0000803472],"study_design_scores_gemma":[0.0004969358,0.0002458841,0.001586819,0.0001288287,0.00001036347,0.00004493993,0.0002298165,0.000005893592,0.9966882,0.0004323645,0.00006585805,0.00006409608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964651,0.0002285193,0.002902452,0.0001985777,0.00004346167,0.00009091148,0.00001740875,0.000001129369,0.00005241959],"genre_scores_gemma":[0.999111,0.00004900544,0.0005625474,0.0001775029,0.0000654791,0.000002225759,0.00001530425,0.000003594453,0.00001336164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002832277,"threshold_uncertainty_score":0.2161267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02898977411013554,"score_gpt":0.2744747840370804,"score_spread":0.2454850099269448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}