{"id":"W2078902726","doi":"10.1038/nchembio.1629","title":"A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":248,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust","keywords":"Binding site; Receptor–ligand kinetics; Kinase; Kinetics; Chemistry; Plasma protein binding; Biophysics; MAPK/ERK pathway; Pyrimidine; Biochemistry; Stereochemistry; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002157856,0.0002429739,0.0002929147,0.00009470011,0.00003435861,0.00001385115,0.0002209156,0.001436588,0.00002051032],"category_scores_gemma":[0.0005192907,0.0001967798,0.0000717029,0.0002367444,0.0001161992,0.000003059059,0.0001312421,0.0006124372,0.00002019672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004531044,"about_ca_system_score_gemma":0.00003860605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005482575,"about_ca_topic_score_gemma":0.00002659517,"domain_scores_codex":[0.9985924,0.00009859866,0.0002343643,0.0005401919,0.00009021656,0.0004441779],"domain_scores_gemma":[0.999345,0.00007025028,0.000114096,0.0002835199,0.00007645882,0.0001106526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007804824,0.00006638663,0.01139465,0.00001015113,0.00003088932,0.000006034985,0.00002622698,5.389735e-7,0.9851373,0.0001554463,0.002622078,0.0004721956],"study_design_scores_gemma":[0.0009849912,0.0004257807,0.0004901736,0.00005075726,0.00001409775,0.00001865479,0.000007286272,0.00002996156,0.9606875,0.00008964667,0.0369068,0.0002943256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973823,0.0002637042,0.0001264423,0.0002575515,0.0001740441,0.0001472688,0.00009066055,0.00002803513,0.001529984],"genre_scores_gemma":[0.9965953,0.00002960742,0.0006051656,0.0009071662,0.0003116376,0.00001807051,0.001246952,0.00002965249,0.0002564339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03428472,"threshold_uncertainty_score":0.9998598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005112793602613707,"score_gpt":0.2249571127614532,"score_spread":0.2198443191588395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}