{"id":"W2078902726","doi":"10.1038/nchembio.1629","title":"A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":248,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust","keywords":"Binding site; Receptor–ligand kinetics; Kinase; Kinetics; Chemistry; Plasma protein binding; Biophysics; MAPK/ERK pathway; Pyrimidine; Biochemistry; Stereochemistry; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004429353,0.0005262523,0.0006483961,0.0003685709,0.0005559347,0.0007250271,0.0009833673,0.0005955969,0.003994131],"category_scores_gemma":[0.0009140382,0.0006622573,0.0006832553,0.0002543113,0.0005020187,0.0007800166,0.0003659329,0.001547783,0.001298744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147241,"about_ca_system_score_gemma":0.0003913512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001415001,"about_ca_topic_score_gemma":0.001292199,"domain_scores_codex":[0.9996291,0.00004068688,0.00001921,0.000117223,0.0001030645,0.00009061996],"domain_scores_gemma":[0.9991266,0.0003126765,0.0002164292,0.0001026575,0.00009443521,0.0001472509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005649026,0.00007772339,0.0004841432,0.0000667105,0.00003536622,0.000192434,0.0000362393,0.0007272781,0.9928999,0.001506196,0.0002602778,0.003148885],"study_design_scores_gemma":[0.0000693107,0.0001553263,0.004656488,0.000008055144,0.00004676238,0.0008294033,0.00002296693,0.01033564,0.9817145,0.0006791675,0.001436141,0.00004623415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560705,0.0008207459,0.03744656,0.0003223155,0.0000843499,0.00006839167,0.0005021885,0.0005404867,0.004144389],"genre_scores_gemma":[0.9891048,0.0001986203,0.007930376,0.0001259688,0.00001383139,0.00005415268,0.0004685825,0.0001449759,0.00195859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003994131,"threshold_uncertainty_score":0.01336169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005112793602613707,"score_gpt":0.2249571127614532,"score_spread":0.2198443191588395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}