{"id":"W2078910490","doi":"10.1074/jbc.m010459200","title":"Apolipoprotein A-I Promotes the Formation of Phosphatidylcholine Core Aldehydes That Are Hydrolyzed by Paraoxonase (PON-1) during High Density Lipoprotein Oxidation with a Peroxynitrite Donor","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Muscular Dystrophy Canada; St. Michael's Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Phosphatidylcholine; Chemistry; Paraoxonase; Lysophosphatidylcholine; Biochemistry; Peroxynitrite; Lipid oxidation; Apolipoprotein B; Lipoprotein; Low-density lipoprotein; Cholesterol; Phospholipid; High-density lipoprotein; TBARS; Lipid peroxidation; Antioxidant; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387835,0.0002410858,0.0003449257,0.00002370456,0.0001246382,0.00002498262,0.0003016843,0.0002697676,0.00005290114],"category_scores_gemma":[0.0001670236,0.0001394378,0.0001548553,0.0001273155,0.0001905313,0.00002481311,0.00007113007,0.000265531,0.000001724054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002988345,"about_ca_system_score_gemma":0.00004846439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005446214,"about_ca_topic_score_gemma":0.0000118805,"domain_scores_codex":[0.9987045,0.00006951971,0.0004839515,0.0002202896,0.0002624242,0.0002592995],"domain_scores_gemma":[0.9984327,0.00003443599,0.0009318806,0.0002827277,0.0001972782,0.0001209588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001523909,0.00017002,0.004351143,0.00004940746,0.00006771568,0.00002561552,0.00002750067,0.00002169732,0.9929465,0.000001220976,0.0002198482,0.000595412],"study_design_scores_gemma":[0.001505377,0.0003437652,0.005149799,0.00009955092,0.00003723309,0.0005819317,0.0001021289,0.00002931264,0.991138,0.00005504041,0.0007666404,0.0001911592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966816,0.002007087,0.0005862978,0.0003785311,0.00002522405,0.0002337164,0.00003799638,0.000009158144,0.00004034812],"genre_scores_gemma":[0.9982648,0.0006405552,0.0003673423,0.00009853391,0.0003025494,0.00001851126,0.0001418175,0.0000134929,0.000152416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808449,"threshold_uncertainty_score":0.568611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904024815883908,"score_gpt":0.2273822844757982,"score_spread":0.2083420363169591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}