{"id":"W2078910840","doi":"10.1002/prp2.110","title":"Jadomycin breast cancer cytotoxicity is mediated by a copper‐dependent, reactive oxygen species–inducing mechanism","year":2015,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Cancer Society; Canadian Imperial Bank of Commerce; Beatrice Hunter Cancer Research Institute","keywords":"Reactive oxygen species; Cytotoxicity; Superoxide dismutase; Thioredoxin reductase; Thioredoxin; Chemistry; Catalase; Glutathione; Antioxidant; Biochemistry; Pharmacology; Intracellular; Molecular biology; Biology; Oxidative stress; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110598,0.0003115132,0.0002822684,0.0001976869,0.0001646993,0.0002916271,0.0001581202,0.0002343145,0.0004510199],"category_scores_gemma":[0.0000966519,0.0001062558,0.0002281447,0.000131433,0.0001578638,0.0001524068,0.0001390367,0.0003089077,0.000189252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447561,"about_ca_system_score_gemma":0.0001765632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734245,"about_ca_topic_score_gemma":0.0006085444,"domain_scores_codex":[0.9998952,0.00002521826,0.00001123526,0.0000179454,0.0000306761,0.00001978468],"domain_scores_gemma":[0.9999002,0.00001632231,0.00002877417,0.00001458056,0.00001805904,0.00002204127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005201154,0.000009208256,0.0001565049,0.00003246992,0.000002792285,0.00002737736,0.000004461684,0.00001573968,0.9990166,0.00002471162,0.00001399509,0.000644097],"study_design_scores_gemma":[0.00001201782,0.0002034344,0.005717003,0.000007458906,0.00001070238,0.0002400628,0.00002205642,0.0003638293,0.9915851,0.00002587619,0.001808763,0.000003577911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882395,0.00604739,0.003524958,0.0001477474,0.00003583038,0.00004499,0.0002143346,0.00008838242,0.001656877],"genre_scores_gemma":[0.9958242,0.001373258,0.001518523,0.00005457185,0.000008795841,0.00002122489,0.000200231,0.000006547983,0.0009927219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004734245,"threshold_uncertainty_score":0.001775801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07433736406191624,"score_gpt":0.3998172843808004,"score_spread":0.3254799203188842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}