{"id":"W2078927162","doi":"10.1371/journal.pone.0067446","title":"Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institutes of Health; National Institute of General Medical Sciences; National Institute on Drug Abuse; U.S. Public Health Service; California Institute of Technology","keywords":"Butyrylcholinesterase; Molecular biology; Immunogenicity; Adenoviridae; Biology; Viral vector; Transduction (biophysics); Chemistry; Genetic enhancement; Recombinant DNA; Enzyme; Antibody; Gene; Immunology; Biochemistry; Acetylcholinesterase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002651959,0.0004946089,0.000364438,0.0004463275,0.0001479112,0.0004410223,0.0003863703,0.0006707311,0.001880827],"category_scores_gemma":[0.0002011294,0.0002106951,0.0003746283,0.0002188572,0.0003620549,0.000331398,0.000243218,0.0008475335,0.0006559298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005255949,"about_ca_system_score_gemma":0.0003407222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007990264,"about_ca_topic_score_gemma":0.001554637,"domain_scores_codex":[0.9996809,0.00003203825,0.00004707818,0.0000829117,0.00007839985,0.00007866514],"domain_scores_gemma":[0.9996772,0.00003913724,0.00009590942,0.00004273207,0.00003153968,0.000113393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007738355,0.00003959468,0.00006853834,0.00001201982,0.000004954505,0.00003211905,0.000008261323,0.00003260566,0.9991178,0.0001033471,0.00002724835,0.0004760581],"study_design_scores_gemma":[0.00003295245,0.0002569683,0.0009693598,0.000005783817,0.00001840853,0.0003170468,0.00001220754,0.0006850209,0.9959163,0.00003235978,0.001748781,0.00000470139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916644,0.0004880849,0.005115886,0.0001145644,0.00005193529,0.00008011083,0.0009082089,0.0002256861,0.001351043],"genre_scores_gemma":[0.9824193,0.0005796928,0.007048069,0.00005672958,0.00002469696,0.0001188061,0.001587459,0.00013016,0.00803512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880827,"threshold_uncertainty_score":0.006291986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03802429142652168,"score_gpt":0.2521811434191492,"score_spread":0.2141568519926275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}