{"id":"W2078962746","doi":"10.1155/2015/303791","title":"Low Mutational Burden of Eight Genes Involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 Pathways in Female Genital Tract Primary Melanomas","year":2015,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Ministry of Health, British Columbia; European Commission","keywords":"GNAQ; HRAS; Neuroblastoma RAS viral oncogene homolog; Mucosal melanoma; MAPK/ERK pathway; Biology; Cancer research; KRAS; Melanoma; DNA mismatch repair; PI3K/AKT/mTOR pathway; Protein kinase B; Mutation; Genetics; Gene; Signal transduction; DNA repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680101,0.0001590678,0.0002159568,0.0007463461,0.0001462634,0.0002641663,0.00009342133,0.0001353721,0.0008423838],"category_scores_gemma":[0.0004788812,0.0001131873,0.0001256058,0.0003826824,0.0002483217,0.000104674,0.0001748879,0.0001147684,0.000131137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252669,"about_ca_system_score_gemma":0.0001325746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004276914,"about_ca_topic_score_gemma":0.0004947332,"domain_scores_codex":[0.9998523,0.00002568768,0.00001685713,0.00004351516,0.00003162108,0.00003011086],"domain_scores_gemma":[0.9998106,0.00005129051,0.00006287549,0.00002387399,0.00002437049,0.0000269461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00064909,0.00005993319,0.572423,0.0001220983,0.0000587319,0.003751869,0.0002899076,0.0003421555,0.4026775,0.00009605534,0.00006023063,0.01946942],"study_design_scores_gemma":[0.00001098877,0.0002482712,0.9399618,0.00001339077,0.0001100622,0.0104742,0.0002213571,0.0005460333,0.04742085,0.0001169116,0.0008697391,0.000006424347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991276,0.0003096116,0.0001934035,0.00000628467,8.006048e-7,0.000003544616,0.00006740573,0.000005147147,0.0002861739],"genre_scores_gemma":[0.9993973,0.0001476029,0.0002304361,0.000003281228,0.000001078122,0.00000417507,0.00006590937,0.000001909311,0.0001483473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008423838,"threshold_uncertainty_score":0.002818108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09880772304763774,"score_gpt":0.341266672220931,"score_spread":0.2424589491732933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}