{"id":"W2078969662","doi":"10.2741/970","title":"The problem of hypernegative supercoiling and r-loop formation in transcription","year":2003,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"DNA supercoil; Topoisomerase; Transcription (linguistics); Mutant; DNA gyrase; Gene; Biology; DNA; Genetics; Cell biology; Molecular biology; Chemistry; DNA replication; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000374968,0.0001212497,0.0002673797,0.00008197932,0.00004679721,0.00001794439,0.0001677095,0.0001326242,2.986642e-7],"category_scores_gemma":[0.000008689952,0.00008694353,0.00005736066,0.000229023,0.0001410883,0.000007494759,0.00002236998,0.00009484382,1.051755e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004102882,"about_ca_system_score_gemma":0.00008639142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001101267,"about_ca_topic_score_gemma":0.00006104266,"domain_scores_codex":[0.9991696,0.00007806605,0.000277721,0.0002258068,0.00008862111,0.0001601816],"domain_scores_gemma":[0.9997213,0.000006957996,0.0001004471,0.0001293656,0.00002110842,0.00002074524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007983445,0.00001587433,0.00001269513,0.0006974043,0.000007515547,3.959264e-7,0.0001256806,0.00000226072,0.009181279,0.0002062476,0.00003442383,0.9897082],"study_design_scores_gemma":[0.0002371202,0.0001256428,0.000005317983,0.001185822,0.00003272867,0.00001258633,0.000323536,0.0001025541,0.006275273,0.000514325,0.9909901,0.0001949999],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008586302,0.9947096,0.003681667,0.00001060388,0.0002241126,0.0003928232,0.00001132228,0.000001231321,0.000109981],"genre_scores_gemma":[0.0007038617,0.9963637,0.002750593,0.00001911426,0.00001064408,0.00004290843,0.00001159142,0.000007869549,0.00008973927],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9909557,"threshold_uncertainty_score":0.3545454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501102716408969,"score_gpt":0.2824405463938384,"score_spread":0.2574295192297487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}