{"id":"W2078969662","doi":"10.2741/970","title":"The problem of hypernegative supercoiling and r-loop formation in transcription","year":2003,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"DNA supercoil; Topoisomerase; Transcription (linguistics); Mutant; DNA gyrase; Gene; Biology; DNA; Genetics; Cell biology; Molecular biology; Chemistry; DNA replication; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000978022,0.0004982805,0.000720472,0.0005463632,0.0005841219,0.001335709,0.0009477395,0.001893906,0.001017086],"category_scores_gemma":[0.001235282,0.0003159492,0.0005436038,0.0005223017,0.002357418,0.001726748,0.0009449053,0.00156795,0.0007393841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009445403,"about_ca_system_score_gemma":0.0004334416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002748071,"about_ca_topic_score_gemma":0.0001512424,"domain_scores_codex":[0.9990879,0.0002297894,0.00007449804,0.0002765803,0.0002196523,0.0001115275],"domain_scores_gemma":[0.9989832,0.0005208901,0.0002616648,0.00007245174,0.00008167439,0.00008015197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000306405,0.0001118757,0.003730395,0.004300604,0.0001249003,0.003981304,0.001491553,0.00629741,0.6124712,0.1631502,0.002940785,0.2010933],"study_design_scores_gemma":[0.00006784914,0.0008206565,0.007262558,0.0007322266,0.0001773753,0.01491225,0.001104839,0.01083774,0.4506055,0.2778527,0.2353623,0.0002639998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1835608,0.6211331,0.1605297,0.01005026,0.001925491,0.00005760066,0.0001126354,0.0005525388,0.02207793],"genre_scores_gemma":[0.7160417,0.2369101,0.02522446,0.001505926,0.003474403,0.0001067359,0.0002739359,0.0001737296,0.01628902],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001893906,"threshold_uncertainty_score":0.006853163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501102716408969,"score_gpt":0.2824405463938384,"score_spread":0.2574295192297487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}