{"id":"W2078982524","doi":"10.1371/journal.pgen.1002301","title":"Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Terry Fox Research Institute","funders":"BC Cancer Agency; Wellcome; Medical Research Council; Canadian Institutes of Health Research; Michael Smith Health Research BC; Wellcome Trust","keywords":"Heterochromatin; Biology; Retrotransposon; Long terminal repeat; DNA methylation; Constitutive heterochromatin; Genetics; Epigenetics; Gene silencing; Transposable element; Gene; Heterochromatin protein 1; Chromatin; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025322,0.0001192428,0.0001100084,0.00000985646,0.0001336285,0.00002805639,0.00033051,0.00008301708,0.000470519],"category_scores_gemma":[0.00001809483,0.00004543867,0.00005415827,0.000233086,0.00002748696,0.00003543708,0.00002645863,0.0001094708,0.00004360543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001556524,"about_ca_system_score_gemma":0.000006251286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007866888,"about_ca_topic_score_gemma":0.0006317192,"domain_scores_codex":[0.9990191,0.00009750359,0.0002259296,0.0002054009,0.0002246193,0.0002273728],"domain_scores_gemma":[0.9997079,0.00006998496,0.00005601336,0.00008270902,0.00002705273,0.00005629314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000009254904,0.0002051301,0.03249776,0.000002400017,0.000008048492,0.000002260466,0.0007617398,8.690516e-7,0.9654864,0.00007215065,0.0001134943,0.0008404678],"study_design_scores_gemma":[0.0003172557,0.0004892459,0.5135512,0.00002717703,0.00002993429,0.00001405307,0.0002457766,0.0004915149,0.4824282,0.001431557,0.0006449108,0.000329168],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998051,0.0001194251,0.000001765055,0.0006536447,0.00003327277,0.0002266557,0.00006350391,0.00002867108,0.0008220638],"genre_scores_gemma":[0.9990699,0.00002460439,0.0002381293,0.0003810148,0.0001027767,0.00003682845,0.00006663945,0.000001434774,0.00007872587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4830582,"threshold_uncertainty_score":0.5151853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05421245481931251,"score_gpt":0.2096283250512293,"score_spread":0.1554158702319168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}