{"id":"W2079013883","doi":"10.1182/blood-2004-06-2125","title":"Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Anaplastic large-cell lymphoma; Protein kinase B; Anaplastic lymphoma kinase; Cancer research; Cell cycle; Lymphoma; PI3K/AKT/mTOR pathway; Kinase; Cell cycle checkpoint; Chemistry; Biology; Signal transduction; Medicine; Apoptosis; Pathology; Immunology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007039564,0.000167333,0.0001852837,0.0002559171,0.0001448752,0.0001892035,0.00008108972,0.000108538,0.0009207631],"category_scores_gemma":[0.0001528255,0.0001145201,0.0001175216,0.0001451872,0.0001562783,0.000113538,0.00009979995,0.0003051845,0.0002428063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236598,"about_ca_system_score_gemma":0.0001594398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005276969,"about_ca_topic_score_gemma":0.001100567,"domain_scores_codex":[0.9999199,0.00001641952,0.000005514457,0.000008243943,0.00002292899,0.00002711781],"domain_scores_gemma":[0.9999452,0.00001431155,0.00001515192,0.000005995128,0.000004448625,0.00001503381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007671559,0.0002576816,0.001207956,0.00004845944,0.0000143109,0.0001495983,0.00002741705,0.0002018152,0.988093,0.0001371559,0.0002589041,0.008836557],"study_design_scores_gemma":[0.0002017524,0.002710981,0.0230545,0.000008164955,0.00002480925,0.0008782405,0.00004286667,0.001927038,0.9670884,0.0001591765,0.003898704,0.000005378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974424,0.001159405,0.0003159609,0.00006015997,0.000009871495,0.000008718712,0.00005997563,0.00002753029,0.000915947],"genre_scores_gemma":[0.9977048,0.0008855538,0.0004202974,0.00002441648,0.000008496477,0.00001538255,0.0001545797,0.000006781841,0.0007797381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009207631,"threshold_uncertainty_score":0.003080308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104427127951263,"score_gpt":0.2281743209163473,"score_spread":0.2177316081212211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}