{"id":"W2079019962","doi":"10.1038/sj.emboj.7600537","title":"Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases","year":2004,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Ontario Genomics; Ontario Genomics Institute; Genome Canada","keywords":"Rhomboid; Biology; Proteases; Proteolysis; Mechanism (biology); Peptide Hydrolases; Biochemistry; Cell biology; Deubiquitinating enzyme; Protease; Enzyme; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790797,0.0001466152,0.0001905839,0.00003891555,0.000241302,0.00003862035,0.0003877901,0.00006070645,0.0001749648],"category_scores_gemma":[0.00004265524,0.00008848488,0.0000693054,0.0001911352,0.000176733,0.00009686693,0.00004221013,0.0005072111,0.0000047616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000561443,"about_ca_system_score_gemma":0.0001550857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000280172,"about_ca_topic_score_gemma":0.000003069771,"domain_scores_codex":[0.9991072,0.00001676746,0.0003035306,0.0001394295,0.0002295059,0.0002035061],"domain_scores_gemma":[0.9990286,0.00002023469,0.0003616375,0.000355671,0.0001284117,0.000105433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008777883,0.000105649,0.00002169425,0.00004648563,0.00007259126,0.00001106259,0.0002697018,0.000831574,0.9667669,0.03074948,0.00001834165,0.00101878],"study_design_scores_gemma":[0.0004588407,0.00005667497,0.000006905978,0.0001328967,0.00004062985,0.000359787,0.0001041603,0.00003633438,0.822677,0.1758627,0.0001574766,0.0001065868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9139398,0.00006427271,0.08232401,0.001704316,0.000007982608,0.0004381714,0.00001153294,0.00009842007,0.001411449],"genre_scores_gemma":[0.9363636,0.00006419487,0.0629909,0.00007891494,0.00009869119,0.0001985355,0.000004071268,0.00002793278,0.0001731325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1451132,"threshold_uncertainty_score":0.3608309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137461342825741,"score_gpt":0.2359782651764262,"score_spread":0.2246036517481688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}