{"id":"W2079045913","doi":"10.1038/mt.2010.49","title":"A Fusion of GMCSF and IL-21 Initiates Hypersignaling Through the IL-21Rα Chain With Immune Activating and Tumoricidal Effects In Vivo","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Cancer research; Cytokine; Biology; Immunology; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578356,0.0003706485,0.0001881374,0.0001514726,0.0001064813,0.0001875229,0.0001340038,0.0002811905,0.0007557336],"category_scores_gemma":[0.0001139175,0.0001164458,0.0003021867,0.0001155029,0.000205887,0.0001317154,0.0002250691,0.0004612881,0.0003442713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835542,"about_ca_system_score_gemma":0.0001580802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002034898,"about_ca_topic_score_gemma":0.000201162,"domain_scores_codex":[0.9998308,0.00002769244,0.00001797176,0.00002863473,0.00004728706,0.00004743838],"domain_scores_gemma":[0.9999049,0.00001268746,0.00003462133,0.00001461257,0.000006939085,0.00002633578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109521,0.00001891087,0.0001044156,0.00001156676,0.000002469918,0.00003617058,0.000006542019,0.00007393977,0.9991228,0.0000796251,0.00001361562,0.00041885],"study_design_scores_gemma":[0.00002860567,0.0004037703,0.001323723,0.000003705362,0.000009003527,0.0002864975,0.000012944,0.0006585768,0.9954035,0.00003606316,0.001831078,0.000002437395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955543,0.0005808154,0.002428766,0.00007629539,0.00002283557,0.00004651633,0.0002340803,0.00003983692,0.001016736],"genre_scores_gemma":[0.995943,0.0003077586,0.002092273,0.00003484388,0.00000797476,0.0000307781,0.0004601358,0.000007711526,0.001115534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007557336,"threshold_uncertainty_score":0.002528131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006008607188984055,"score_gpt":0.2172288834141525,"score_spread":0.2112202762251685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}