{"id":"W2079053066","doi":"10.1007/s10549-015-3347-x","title":"Prevalence of PALB2 mutations in the Creighton University Breast Cancer Family Registry","year":2015,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; Women's College Hospital; University of Toronto","funders":"","keywords":"PALB2; Breast cancer; Proband; Medicine; Cancer; Oncology; Family history; Internal medicine; Mutation; Germline mutation; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006214615,0.0001633011,0.0002810661,0.00327776,0.0006899948,0.0007802128,0.0009981318,0.000543241,0.006485165],"category_scores_gemma":[0.002886872,0.0003089923,0.0002593597,0.00296967,0.0002912129,0.0006766455,0.000724047,0.0004190259,0.0006304086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007866885,"about_ca_system_score_gemma":0.0009636502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0467582,"about_ca_topic_score_gemma":0.03399266,"domain_scores_codex":[0.9992048,0.000138765,0.00006706845,0.0002333506,0.0001707366,0.0001853692],"domain_scores_gemma":[0.9980919,0.000286743,0.0007438517,0.0001411637,0.00030112,0.0004351717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003426498,0.00001826236,0.9975756,0.00000646336,0.00001524517,0.0001975612,0.00007662314,0.00003494,0.0001900297,0.00004587238,0.0009322928,0.0008729129],"study_design_scores_gemma":[0.000004244972,0.00001478878,0.9982874,0.00001113359,0.000009065333,0.0005690182,0.000360536,0.0001460366,0.00008095571,0.00001638886,0.0004953336,0.000005041087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926007,0.0003131097,0.00005676633,0.0002513996,0.000009741555,0.00001392027,0.004458013,0.00001928028,0.002277096],"genre_scores_gemma":[0.9968963,0.000247076,0.00006864516,0.000098394,0.00001064228,0.0000178653,0.001851621,0.000009467897,0.0007999467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0467582,"threshold_uncertainty_score":0.0929721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05991812753315464,"score_gpt":0.3503696698872794,"score_spread":0.2904515423541247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}