{"id":"W2079061687","doi":"10.1038/ncomms5431","title":"A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Genentech; Centre National de la Recherche Scientifique; Fondation ARC pour la Recherche sur le Cancer; Ligue Contre le Cancer; Fonds National de la Recherche Luxembourg; Institut National de la Santé et de la Recherche Médicale; European Commission","keywords":"PTEN; Suppressor; PI3K/AKT/mTOR pathway; Biosensor; Phosphatase; Chemistry; Cell biology; Function (biology); Protein kinase B; Cancer research; Signal transduction; Biology; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005029881,0.0006196269,0.0004369617,0.0004857189,0.0004020264,0.0006914018,0.001321063,0.001358861,0.001296469],"category_scores_gemma":[0.0004764646,0.0003849405,0.0003672782,0.0006014213,0.000418583,0.0007009572,0.0006021105,0.001372658,0.0005638656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009029993,"about_ca_system_score_gemma":0.0003863672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005148071,"about_ca_topic_score_gemma":0.000968972,"domain_scores_codex":[0.9995003,0.00006791886,0.00002375334,0.0001332716,0.0002061992,0.00006857282],"domain_scores_gemma":[0.9997033,0.0001086294,0.00005924101,0.00003904059,0.00004502664,0.00004465767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003435792,0.00003205114,0.0001124874,0.00004703679,0.000007613015,0.0000451405,0.00002985956,0.00007907263,0.9966649,0.0004436618,0.0002242485,0.00227948],"study_design_scores_gemma":[0.0000181674,0.0001418565,0.0008337162,0.00000586558,0.0000187933,0.000159234,0.00004601854,0.004437134,0.991127,0.0002865547,0.002912774,0.00001287063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7822356,0.003892244,0.1984137,0.002216934,0.0008264357,0.0001983198,0.00160633,0.002004905,0.008605563],"genre_scores_gemma":[0.8967845,0.002800808,0.08726934,0.0008647594,0.0001291473,0.0004565619,0.0009820197,0.000152627,0.0105602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358861,"threshold_uncertainty_score":0.006551743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007815331006632112,"score_gpt":0.2713044351659929,"score_spread":0.2634891041593608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}