{"id":"W2079109047","doi":"10.1021/jm030573x","title":"Peptide-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Structure−Activity Relationship at the<i>C</i>-Terminal Position","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Protease; NS3; Cysteine protease; Cysteine; Tetrapeptide; Peptide; Residue (chemistry); Norvaline; Enzyme; Biochemistry; Amino acid; Valine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900621,0.0004076178,0.0003111158,0.0002232375,0.0001118362,0.0003386697,0.0002879021,0.0003448386,0.0007547911],"category_scores_gemma":[0.0002205004,0.00013578,0.0002008283,0.0001504687,0.0001673411,0.000263948,0.0001221223,0.0004617139,0.0002415812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310603,"about_ca_system_score_gemma":0.0001482497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002475879,"about_ca_topic_score_gemma":0.0004877982,"domain_scores_codex":[0.9998785,0.00002885312,0.00001144784,0.00001723349,0.00003157071,0.00003237374],"domain_scores_gemma":[0.9998327,0.00005200838,0.00004604854,0.000009114295,0.00002423941,0.0000359259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004687339,0.0001939424,0.0002934292,0.0001191203,0.00001940418,0.0001009722,0.00002525204,0.0009288162,0.9888924,0.0002133586,0.00004577126,0.008698683],"study_design_scores_gemma":[0.0001077283,0.004839947,0.002089165,0.000008781447,0.00004371096,0.0004117813,0.000008251837,0.001226439,0.9886812,0.00006122547,0.002509339,0.00001241652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818455,0.01266881,0.002495261,0.00007837835,0.00002611953,0.00009128235,0.0001650449,0.00004094885,0.002588727],"genre_scores_gemma":[0.9903539,0.005131771,0.002684372,0.00006358545,0.00002396757,0.00003764925,0.0002778583,0.000008766558,0.001418144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007547911,"threshold_uncertainty_score":0.002525091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696891110781492,"score_gpt":0.2933294413484761,"score_spread":0.2763605302406612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}