{"id":"W2079109047","doi":"10.1021/jm030573x","title":"Peptide-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Structure−Activity Relationship at the<i>C</i>-Terminal Position","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Protease; NS3; Cysteine protease; Cysteine; Tetrapeptide; Peptide; Residue (chemistry); Norvaline; Enzyme; Biochemistry; Amino acid; Valine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00075378,0.0001851058,0.0003757038,0.00007353497,0.0002095356,0.00001404666,0.0002651437,0.0001789367,0.0004015627],"category_scores_gemma":[0.001387023,0.000106678,0.0002682452,0.0003399118,0.0004874933,0.0001093367,0.00006445357,0.001256629,0.000004194796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007973976,"about_ca_system_score_gemma":0.001266805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004341727,"about_ca_topic_score_gemma":0.0001200441,"domain_scores_codex":[0.9970801,0.0001343981,0.0006333414,0.0001646308,0.001728741,0.0002587328],"domain_scores_gemma":[0.9979157,0.0002269832,0.0007256071,0.000406265,0.0004746724,0.0002507704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001014548,0.0002217766,0.2084799,0.0005221799,0.00008262326,0.0005256446,0.0002338218,0.0001617176,0.7849559,0.000006469599,0.001511795,0.002283647],"study_design_scores_gemma":[0.002555874,0.000361875,0.1758001,0.00130773,0.0001931939,0.002174391,0.00003924752,0.00003750487,0.8165935,0.000225883,0.0006117193,0.00009899063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921398,0.0003270724,0.0001332517,0.006113558,0.0001536114,0.0003316077,0.00004428103,0.000008092252,0.0007487987],"genre_scores_gemma":[0.9985158,0.00004227077,0.0001992467,0.0002346062,0.0006815328,0.000007022638,0.000008343772,0.00002202329,0.0002891985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03267975,"threshold_uncertainty_score":0.5459497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696891110781492,"score_gpt":0.2933294413484761,"score_spread":0.2763605302406612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}