{"id":"W2079113820","doi":"10.1007/s11693-014-9151-9","title":"When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage","year":2014,"lang":"en","type":"review","venue":"Systems and Synthetic Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA damage; Cell biology; G2-M DNA damage checkpoint; Biology; Kinase; DNA repair; CHEK1; Cell cycle checkpoint; Genome instability; Cell cycle; Checkpoint Kinase 2; Polo-like kinase; DNA re-replication; DNA; Cell; Genetics; Protein-Serine-Threonine Kinases; Eukaryotic DNA replication; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007159942,0.0003310958,0.001250746,0.0001993492,0.00004975135,0.00002489301,0.0002394942,0.0007119278,0.000005251834],"category_scores_gemma":[0.0002274915,0.0002616211,0.0001365818,0.0000875273,0.0001309877,0.000002828011,0.0002495107,0.0001775924,0.000006251841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002227579,"about_ca_system_score_gemma":0.0001095273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003603837,"about_ca_topic_score_gemma":0.0002335135,"domain_scores_codex":[0.9976905,0.0006355321,0.0006930314,0.0006490343,0.00007431162,0.0002576112],"domain_scores_gemma":[0.9988483,0.0001618575,0.0003107506,0.0004932533,0.00006235712,0.0001234622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001097106,0.0003479107,0.00008886671,0.01839838,0.000350639,0.00003020885,0.00113596,0.00004708959,0.4084422,0.005106214,0.000130027,0.5658128],"study_design_scores_gemma":[0.0004267037,0.00108134,0.00001760899,0.003869147,0.0002582121,0.00007217783,0.0007216497,0.0001763287,0.004073771,0.0007479879,0.9878317,0.0007233768],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07527489,0.9208458,0.002492929,0.00001830787,0.0002065323,0.0008760885,0.0001307232,0.000008792007,0.0001459337],"genre_scores_gemma":[0.3050357,0.6934065,0.0009545626,0.00001623378,0.00009097284,0.0001327879,0.0001930599,0.00004088309,0.0001293617],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9877017,"threshold_uncertainty_score":0.9999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721269132863017,"score_gpt":0.2808035860383052,"score_spread":0.253590894709675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}