{"id":"W2079129006","doi":"10.1186/1471-2202-8-73","title":"Calcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology","year":2007,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Alzheimer Society; Saskatchewan Health Research Foundation; AstraZeneca","keywords":"Monoamine oxidase; Hippocampal formation; Monoamine neurotransmitter; Intracellular; Oxidative stress; Alzheimer's disease; Biochemistry; Chemistry; Calcium; Serotonin; Calcium in biology; Biology; Cell biology; Internal medicine; Endocrinology; Enzyme; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298669,0.0004455725,0.0005533242,0.0002406059,0.0003567582,0.0006567351,0.0004945992,0.0004267181,0.00158812],"category_scores_gemma":[0.0001891227,0.0002080873,0.0004403088,0.0003037303,0.0004030022,0.0003979653,0.0003449826,0.0009766346,0.0005525008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000681961,"about_ca_system_score_gemma":0.0004635005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003354585,"about_ca_topic_score_gemma":0.005546957,"domain_scores_codex":[0.9997922,0.00001366741,0.00003364659,0.00005186269,0.00005184849,0.00005683142],"domain_scores_gemma":[0.9997858,0.00003305614,0.00004397129,0.0000385045,0.000048642,0.00005002793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000233677,0.00005075374,0.0003261116,0.00007066136,0.00001060542,0.0001412879,0.00003518141,0.00001809439,0.9982677,0.0000443052,0.00007344697,0.0007281514],"study_design_scores_gemma":[0.00009679017,0.0002917577,0.02020384,0.00002240749,0.00006600446,0.0005079223,0.00015595,0.0005810313,0.9754634,0.000141109,0.002460201,0.000009602929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980928,0.009978426,0.003259677,0.0006934258,0.0002010255,0.00007099339,0.001131794,0.0001571748,0.003579417],"genre_scores_gemma":[0.9887409,0.003908416,0.00255101,0.0001568397,0.0000567818,0.0001422854,0.0009160631,0.00003028354,0.003497474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003354585,"threshold_uncertainty_score":0.006670117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04716321767265316,"score_gpt":0.338095695670968,"score_spread":0.2909324779983148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}