{"id":"W2079141762","doi":"10.1042/bj3460313","title":"Inhibition of atrial natriuretic peptide (ANP) C receptor expression by antisense oligodeoxynucleotides in A10 vascular smooth-muscle cells is associated with attenuation of ANP-C-receptor-mediated inhibition of adenylyl cyclase","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Genentech; Medical Research Council Canada","keywords":"NPR2; Adenylyl cyclase; ADCY9; NPR1; Receptor; Atrial natriuretic peptide; ADCY10; Chemistry; Internal medicine; Endocrinology; Natriuretic peptide; Biology; Biochemistry; Medicine; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002307919,0.0004966631,0.0003607752,0.0001333864,0.0001558992,0.0003164773,0.0002560767,0.0003574114,0.001053835],"category_scores_gemma":[0.0001373681,0.0002122554,0.0003269927,0.0001226021,0.0002670142,0.0001312123,0.0001316418,0.0008377156,0.0004335044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141725,"about_ca_system_score_gemma":0.0003163989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559923,"about_ca_topic_score_gemma":0.001991513,"domain_scores_codex":[0.9997388,0.00003964681,0.00003358382,0.00005755301,0.00006938763,0.0000610288],"domain_scores_gemma":[0.9997515,0.00006458174,0.00005558609,0.00002128248,0.00003117645,0.00007592126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002743381,0.00001351087,0.00001875344,0.000008274923,0.000001703783,0.000008601039,0.000005811706,0.00001061934,0.9997808,0.00001787709,0.000005296395,0.000101314],"study_design_scores_gemma":[0.00002388624,0.0008890192,0.001449473,0.000003965577,0.00001892582,0.000107746,0.00002702988,0.0006828592,0.995551,0.00001273723,0.001228722,0.000004874855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957221,0.000755071,0.002112969,0.00007084136,0.00007824556,0.00003764327,0.000199056,0.00006119296,0.0009628587],"genre_scores_gemma":[0.9888037,0.001187675,0.005528505,0.0001033966,0.00002620513,0.0001038758,0.000590269,0.00002596463,0.00363059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559923,"threshold_uncertainty_score":0.003525436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00784272085003391,"score_gpt":0.2235526577205018,"score_spread":0.2157099368704679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}