{"id":"W2079172245","doi":"10.1002/jcb.10517","title":"hMad4, c‐Myc endogenous inhibitor, induces a replicative senescence‐like state when overexpressed in human fibroblasts","year":2003,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute on Aging","keywords":"Biology; Transactivation; Molecular biology; Cell growth; Cell culture; Northern blot; clone (Java method); Senescence; Complementary DNA; Cell biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005406811,0.0003252015,0.0006386992,0.000197915,0.00009151185,0.00004401629,0.0002650475,0.0002239691,0.0001637904],"category_scores_gemma":[0.0002461484,0.0002914786,0.0002299387,0.0003008244,0.0001635858,0.0001356378,0.0000459453,0.0007155569,0.000007696767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194074,"about_ca_system_score_gemma":0.0004932013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003643061,"about_ca_topic_score_gemma":0.000002703706,"domain_scores_codex":[0.9974195,0.0001114275,0.0009693876,0.000405782,0.0006325042,0.0004614352],"domain_scores_gemma":[0.9979669,0.00007435757,0.0007044022,0.0005478875,0.0003329054,0.0003735182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855463,0.0004339224,0.003522073,0.0002542683,0.00007652921,0.0008146684,0.0009470624,0.000004323701,0.9927266,0.000009391296,0.0006949367,0.0003306835],"study_design_scores_gemma":[0.002128706,0.0003608227,0.0004999737,0.0007333654,0.00004996614,0.001045197,0.0005685462,0.000002842226,0.9925505,0.0002457644,0.001536841,0.0002774702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952738,0.002366,0.000173746,0.0001373975,0.0001384225,0.0002024983,0.0000129201,0.00002042619,0.001674782],"genre_scores_gemma":[0.9972739,0.0001584843,0.001065781,0.0001473773,0.0002107472,0.000005256722,0.00001813587,0.00004006131,0.001080261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030221,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095197985270245,"score_gpt":0.2494792147636777,"score_spread":0.2285272349109752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}