{"id":"W2079178739","doi":"10.1016/j.bbmt.2009.04.015","title":"HLA-A Disparities Illustrate Challenges for Ranking the Impact of HLA Mismatches on Bone Marrow Transplant Outcomes in the United States","year":2009,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; Takeda Oncology; University of California, San Francisco; Health Resources and Services Administration; National Institutes of Health; Otsuka Pharmaceutical; Astellas Pharma; Therakos; Kiadis Pharma; Association of Medical Microbiology and Infectious Disease Canada; American Society for Blood and Marrow Transplantation; Teva Pharmaceutical Industries; WellPoint; HistoGenetics; CellGenix; Medical College of Wisconsin; StemCyte; Enzon Pharmaceuticals; U.S. Navy; Centers for Disease Control and Prevention; Celgene; Osiris Therapeutics; Pfizer; Baxter International; U.S. Department of Health and Human Services; Astellas Pharma US; Amgen; Blue Cross and Blue Shield Association; Be The Match Foundation; Bayer HealthCare; U.S. Department of Defense","keywords":"Human leukocyte antigen; Medicine; Odds ratio; Immunology; Confidence interval; Histocompatibility; Histocompatibility Testing; Bone marrow; Hematopoietic stem cell transplantation; Bone marrow transplantation; Allele; Transplantation; Internal medicine; Genetics; Biology; Antigen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007422353,0.0002461021,0.0003232968,0.00118506,0.0006025023,0.001281124,0.0003608854,0.0004046843,0.001058197],"category_scores_gemma":[0.01529416,0.0001251732,0.0003490857,0.001489782,0.0004944541,0.001150743,0.001584879,0.0007053007,0.00009412148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006667842,"about_ca_system_score_gemma":0.0008804548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.011394,"about_ca_topic_score_gemma":0.02723082,"domain_scores_codex":[0.996126,0.002946079,0.000241632,0.0001742905,0.0003878433,0.0001242102],"domain_scores_gemma":[0.9914101,0.004506595,0.002783201,0.000445282,0.0004048728,0.0004499885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009084633,0.00005114343,0.9537191,0.00004869178,0.0001172144,0.0000756826,0.0004640204,0.001047534,0.00008970508,0.002728025,0.001374669,0.04019348],"study_design_scores_gemma":[0.00002300499,0.0003116116,0.956381,0.0003790245,0.0001619503,0.0006189784,0.005024574,0.01494438,0.0002828074,0.01735532,0.004471206,0.00004599174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805219,0.003755254,0.004455036,0.006072681,0.0000462287,0.00003111066,0.0004012338,0.00003181831,0.004684712],"genre_scores_gemma":[0.9975415,0.0007093025,0.001249588,0.0003294919,0.0000237832,0.000008741693,0.00008812949,0.000003191167,0.0000462992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.011394,"threshold_uncertainty_score":0.03925365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03348931806196104,"score_gpt":0.2969317434040188,"score_spread":0.2634424253420578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}