{"id":"W2079204784","doi":"10.1161/circresaha.111.300119","title":"Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination","year":2013,"lang":"en","type":"article","venue":"Circulation Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"British Heart Foundation; Wellcome Trust","keywords":"Proinflammatory cytokine; Ubiquitin; Cell biology; Tumor necrosis factor alpha; Inflammation; Biology; Deubiquitinating enzyme; Hypoxia-inducible factors; Transcription factor; Signal transduction; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158053,0.0004031517,0.0002565577,0.00017379,0.0002419865,0.0003139398,0.000289451,0.0003255773,0.001261521],"category_scores_gemma":[0.0001723921,0.0001307449,0.0002916769,0.0001553706,0.0003828589,0.0002679469,0.0001713727,0.0004210942,0.0002869804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006265503,"about_ca_system_score_gemma":0.0003310835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004571222,"about_ca_topic_score_gemma":0.0009831768,"domain_scores_codex":[0.9998538,0.00002665385,0.00001845568,0.00003445057,0.00003314478,0.00003341064],"domain_scores_gemma":[0.9998666,0.00001500806,0.00005752838,0.00001791378,0.00001960452,0.0000233813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000324785,0.00004805693,0.0004074626,0.00009280352,0.000008506645,0.0000459714,0.00001087479,0.0001001963,0.9971456,0.0002110661,0.0000557182,0.001548953],"study_design_scores_gemma":[0.00003688626,0.000205664,0.002291871,0.000006597587,0.00001533113,0.0001615073,0.00001514206,0.0004303388,0.9939263,0.00003975555,0.002866416,0.000004283534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849713,0.004394544,0.007080733,0.0004902434,0.00006984637,0.0001326588,0.0007885001,0.000126545,0.001945633],"genre_scores_gemma":[0.9925174,0.001712818,0.00330156,0.00007254924,0.00001264359,0.00007569461,0.0003942825,0.000012731,0.001900314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261521,"threshold_uncertainty_score":0.004545927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267742111508319,"score_gpt":0.3207233829266078,"score_spread":0.2880459618115246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}