{"id":"W2079216108","doi":"10.1074/jbc.m113.485326","title":"Determination of an Angiotensin II-regulated Proteome in Primary Human Kidney Cells by Stable Isotope Labeling of Amino Acids in Cell Culture (SILAC)","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôtel-Dieu de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Amgen Canada; Kidney Foundation of Canada; Amgen","keywords":"Stable isotope labeling by amino acids in cell culture; Angiotensin II; Proteome; Kidney; Biology; Angiotensin receptor; Chemistry; Molecular biology; Proteomics; Receptor; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004757477,0.0002048891,0.0008897743,0.00008806925,0.00003169416,0.000008805704,0.000167575,0.0003954959,0.00005994865],"category_scores_gemma":[0.000200929,0.0001360829,0.0001432513,0.0002711254,0.0001405736,0.0001211241,0.00008284047,0.0003961031,8.830439e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524087,"about_ca_system_score_gemma":0.00007545514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003680388,"about_ca_topic_score_gemma":6.933338e-7,"domain_scores_codex":[0.9980382,0.00008259418,0.001118248,0.0002132406,0.0002951985,0.000252558],"domain_scores_gemma":[0.9982671,0.00003802087,0.0008190502,0.0001933126,0.0005263132,0.000156226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119898,0.0004514371,0.03994282,0.0001806246,0.0000238245,0.00003850956,0.0002770543,0.000005188967,0.9579573,9.664331e-8,0.0008093368,0.00019392],"study_design_scores_gemma":[0.001738049,0.0007532894,0.06956944,0.0006319999,0.00003057703,0.00006388577,0.0001545614,0.00005494109,0.9267514,0.00002536766,0.00009768343,0.0001288321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982202,0.0007073433,0.000009525424,0.0001797098,0.00002948413,0.0003743402,0.00001300526,0.000008411911,0.0004579616],"genre_scores_gemma":[0.9942612,0.00005971464,0.00501232,0.00006958468,0.00007985377,0.000005500733,0.00003312577,0.000012099,0.0004665828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03120592,"threshold_uncertainty_score":0.5549299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434438819111002,"score_gpt":0.2473383816089144,"score_spread":0.2329939934178043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}