{"id":"W207924865","doi":"10.1212/wnl.80.7_supplement.p07.128","title":"Clinical Efficacy of BG-12 (Dimethyl Fumarate) for Relapsing–Remitting Multiple Sclerosis (RRMS) According to Prior Therapy: An Integrated Analysis of the Phase 3 DEFINE and CONFIRM Studies (P07.128)","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Relapsing remitting; Dimethyl fumarate; Multiple sclerosis; Medicine; Internal medicine; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00482367,0.0008315342,0.002202832,0.0005624632,0.0003628364,0.0006591006,0.000462384,0.0005343436,0.001236133],"category_scores_gemma":[0.001676205,0.0003068683,0.001476131,0.000375997,0.0003847397,0.0005030844,0.000420356,0.001044473,0.000247933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005937908,"about_ca_system_score_gemma":0.000884094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000795415,"about_ca_topic_score_gemma":0.003157818,"domain_scores_codex":[0.9978964,0.00125527,0.0001181048,0.00018533,0.0003082385,0.0002366019],"domain_scores_gemma":[0.9983914,0.0004191239,0.0005934036,0.0001474272,0.0001701076,0.0002784713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7447533,0.009107863,0.1003268,0.0004712599,0.01051909,0.00006860164,0.0001241111,0.001228229,0.04092028,0.0001424688,0.001349,0.09098892],"study_design_scores_gemma":[0.07809515,0.410608,0.4689985,0.00005727271,0.01198675,0.0003435796,0.0001432505,0.003042662,0.02134369,0.0002050855,0.005085735,0.00009035974],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958279,0.001954445,0.0004057105,0.00009590582,0.00003005793,0.0003290382,0.0006512062,0.00003541929,0.0006703441],"genre_scores_gemma":[0.9966427,0.0004047232,0.0009194825,0.0001061839,0.00004025333,0.0001993104,0.001153594,0.00001378595,0.0005199632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00482367,"threshold_uncertainty_score":0.02551031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017899256232748,"score_gpt":0.3819650589940071,"score_spread":0.2801751333707323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}