{"id":"W2079271935","doi":"10.1002/ddr.10102","title":"Design, syntheses, and evaluation of 2,3‐diphenylcycloprop‐2‐en‐1‐ones and oxime derivatives as potential cyclooxygenase‐2 (COX‐2) inhibitors with analgesic‐antiinflammatory activity","year":2002,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Oxime; Celecoxib; Cyclooxygenase; Pharmacology; Substituent; Analgesic; Stereochemistry; In vivo; Medicinal chemistry; Enzyme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005794185,0.0002987297,0.0004704309,0.0005602958,0.0003440026,0.00005207013,0.0001104907,0.0001473279,0.0002161836],"category_scores_gemma":[0.0007900777,0.0002291997,0.0000352959,0.0004743896,0.0004958031,0.0002622518,0.0001504055,0.0004529921,0.00003837667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970881,"about_ca_system_score_gemma":0.0005862242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006000647,"about_ca_topic_score_gemma":0.00002378768,"domain_scores_codex":[0.9951531,0.001143621,0.0003807561,0.0005555251,0.002199271,0.0005677466],"domain_scores_gemma":[0.9978625,0.0006869847,0.0001425405,0.0002987677,0.0006870038,0.0003222655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004481002,0.00153473,0.0885422,0.003387068,0.001606019,0.0009030916,0.0327822,0.0001498867,0.3520761,0.0001909187,0.002789153,0.5115577],"study_design_scores_gemma":[0.003738475,0.0005567599,0.2913322,0.001148457,0.0001990457,0.0001665452,0.001942922,0.007892989,0.6912983,0.0001049227,0.001023791,0.0005955417],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956256,0.001225187,0.0001681571,0.0003984074,0.00006469525,0.001646479,0.000001533049,0.00004413769,0.0008258339],"genre_scores_gemma":[0.9969383,0.0003829529,0.001901655,0.00001365095,0.0001258459,0.0001749876,0.000005603905,0.00004347399,0.0004135628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5109621,"threshold_uncertainty_score":0.9346492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05953338904036524,"score_gpt":0.3214187949371493,"score_spread":0.261885405896784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}