{"id":"W2079289532","doi":"10.1002/bies.10355","title":"Chronic activation of ERK and neurodegenerative diseases","year":2003,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"MAPK/ERK pathway; Neurodegeneration; Dual-specificity phosphatase; DUSP6; Compartmentalization (fire protection); Kinase; Cell biology; Extracellular; Phosphatase; Biology; Subcellular localization; Neuroscience; Phosphorylation; Medicine; Disease; Biochemistry; Protein phosphatase 2; Enzyme; Pathology; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006472068,0.0002099046,0.0004189888,0.0000591498,0.00004599465,0.00001285711,0.0000758906,0.0002005598,0.00001560605],"category_scores_gemma":[0.00004562558,0.0001751937,0.0001506545,0.00009278733,0.00007781244,0.000002451106,0.00005245307,0.0000631692,0.000001912329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000180345,"about_ca_system_score_gemma":0.0002211132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002272955,"about_ca_topic_score_gemma":0.000001111022,"domain_scores_codex":[0.9991049,0.0001362001,0.0002445517,0.0003127859,0.00008623848,0.0001153433],"domain_scores_gemma":[0.9994218,0.00001179425,0.0002282179,0.0002343693,0.00004722908,0.00005659958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000871815,0.00004288249,0.00001016543,0.006940414,0.0001406124,0.000001845208,0.000005637984,0.000007982572,0.009456229,0.001130724,0.000540881,0.9817139],"study_design_scores_gemma":[0.0001425649,0.00009924987,0.000004775215,0.001077727,0.0001529837,0.000006620469,0.000001865967,0.000004243809,0.009235921,0.00002660845,0.9890437,0.0002037071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009408504,0.9985592,0.0006298016,0.000005888576,0.0000575953,0.0003456758,0.00008456877,0.000006140169,0.0002170845],"genre_scores_gemma":[0.0007980844,0.9980323,0.0001237729,0.00001707516,0.0002551371,0.00004849356,0.0004767524,0.00002776029,0.0002206573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885029,"threshold_uncertainty_score":0.7144191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642381310741601,"score_gpt":0.296091416886141,"score_spread":0.269667603778725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}