{"id":"W2079289532","doi":"10.1002/bies.10355","title":"Chronic activation of ERK and neurodegenerative diseases","year":2003,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"MAPK/ERK pathway; Neurodegeneration; Dual-specificity phosphatase; DUSP6; Compartmentalization (fire protection); Kinase; Cell biology; Extracellular; Phosphatase; Biology; Subcellular localization; Neuroscience; Phosphorylation; Medicine; Disease; Biochemistry; Protein phosphatase 2; Enzyme; Pathology; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004004864,0.0009929792,0.001064493,0.001493717,0.0003179562,0.0008200341,0.0007290189,0.001482683,0.003201855],"category_scores_gemma":[0.000340808,0.0001931159,0.000230439,0.001783657,0.0004792698,0.001272429,0.0005907603,0.001142978,0.00417454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007077833,"about_ca_system_score_gemma":0.000715014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009476574,"about_ca_topic_score_gemma":0.001650037,"domain_scores_codex":[0.9998878,0.0000163692,0.00001625973,0.00002756607,0.00004051308,0.00001147894],"domain_scores_gemma":[0.9998651,0.00003632969,0.00001979665,0.000005935661,0.00005004273,0.00002287034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001201356,0.00005684464,0.0003458638,0.005903508,0.00006598447,0.0008309809,0.00007497234,0.0003598262,0.004037017,0.00543494,0.0406366,0.9421333],"study_design_scores_gemma":[0.00001625764,0.00004794751,0.0009997756,0.0009692025,0.00004196086,0.002966329,0.00006055944,0.0000615852,0.0009969764,0.002837744,0.9909889,0.0000126887],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002877608,0.9964154,0.0003023093,0.0004708777,0.0003315241,0.000004292848,0.00001683461,0.00001469483,0.002156324],"genre_scores_gemma":[0.001639579,0.9951535,0.0003122608,0.000330591,0.0002911315,0.000008176432,0.00003608048,0.000002740379,0.002225841],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003201855,"threshold_uncertainty_score":0.01071125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642381310741601,"score_gpt":0.296091416886141,"score_spread":0.269667603778725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}