{"id":"W2079311516","doi":"10.1159/000089290","title":"Downregulation of Human Kallikrein 10 <i> (KLK10/NES1)</i> by CpG Island Hypermethylation in Breast, Ovarian and Prostate Cancers","year":2005,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"DNA methylation; Cancer research; Demethylating agent; CpG site; Biology; LNCaP; Bisulfite sequencing; Prostate cancer; Molecular biology; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007954957,0.0001347732,0.0001233021,0.0002022816,0.0001342594,0.0001610097,0.0001201991,0.0001378631,0.002151366],"category_scores_gemma":[0.000116261,0.0001360768,0.0001069731,0.00008684322,0.000166532,0.00007057282,0.00009566427,0.0002378152,0.0003043329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307196,"about_ca_system_score_gemma":0.0001933958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00257352,"about_ca_topic_score_gemma":0.004300047,"domain_scores_codex":[0.9999468,0.000008358082,0.000004161516,0.00001363588,0.00001325305,0.00001376117],"domain_scores_gemma":[0.9999191,0.00001454785,0.00002431367,0.00000832795,0.000009701084,0.00002411644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002707018,0.00001861471,0.002578491,0.00002258773,0.00001020023,0.00009619519,0.00004089987,0.00008123401,0.9942555,0.00008543782,0.0001915545,0.002348673],"study_design_scores_gemma":[0.00007611775,0.0003542714,0.1657528,0.000009459371,0.0000614946,0.001831212,0.0001570125,0.00106176,0.8256543,0.0001592525,0.004872017,0.00001030662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970077,0.0005784846,0.0008463857,0.0001033928,0.00001391509,0.000007958715,0.0003269305,0.00004918113,0.001066077],"genre_scores_gemma":[0.9966912,0.000249036,0.0003206563,0.00003570532,0.000003897011,0.00001094621,0.0003073299,0.00001229587,0.002368963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00257352,"threshold_uncertainty_score":0.007197022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008447593090272713,"score_gpt":0.2546867115193116,"score_spread":0.2462391184290389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}