{"id":"W2079311516","doi":"10.1159/000089290","title":"Downregulation of Human Kallikrein 10 <i> (KLK10/NES1)</i> by CpG Island Hypermethylation in Breast, Ovarian and Prostate Cancers","year":2005,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"DNA methylation; Cancer research; Demethylating agent; CpG site; Biology; LNCaP; Bisulfite sequencing; Prostate cancer; Molecular biology; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359178,0.0002213044,0.0004684146,0.0002297273,0.00008468567,0.00001129912,0.00007184006,0.0001469026,0.0004762266],"category_scores_gemma":[0.00004177439,0.0002005855,0.00006211432,0.0002440547,0.0002360641,0.0001221089,0.00003420549,0.0001004008,0.00001192086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302354,"about_ca_system_score_gemma":0.0001133392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004357521,"about_ca_topic_score_gemma":0.001580607,"domain_scores_codex":[0.9984709,0.0001018619,0.0005609614,0.0003951098,0.0001315497,0.0003395996],"domain_scores_gemma":[0.9992297,0.00007420453,0.0002487019,0.0002275187,0.0001094721,0.0001103586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005253187,0.000139917,0.1746545,0.00008558124,0.00005845541,0.000007951184,0.0008227305,0.0001078366,0.8003612,0.003633533,0.001964639,0.01763836],"study_design_scores_gemma":[0.00435551,0.0005232424,0.9640973,0.0001186304,0.00008399793,0.0001289438,0.0000384866,0.003809585,0.01002917,0.001124426,0.01536598,0.0003247636],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994947,0.001804598,0.00006340665,0.001255617,0.00006627052,0.0004682972,0.0001072512,0.0000493933,0.00123818],"genre_scores_gemma":[0.9970939,0.00008681224,0.0002420554,0.0001579772,0.0002368336,0.00003771321,0.0005896637,0.00002622282,0.001528806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.790332,"threshold_uncertainty_score":0.8179641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008447593090272713,"score_gpt":0.2546867115193116,"score_spread":0.2462391184290389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}