{"id":"W2079329077","doi":"10.1074/jbc.m110266200","title":"FOXC1 Transcriptional Regulation Is Mediated by N- and C-terminal Activation Domains and Contains a Phosphorylated Transcriptional Inhibitory Domain","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Phosphoprotein; Phosphorylation; Transcriptional regulation; Nuclear localization sequence; Transcription factor; Biology; Transcription (linguistics); Cell biology; Gene; GATAD2B; NLS; Nuclear protein; Regulation of gene expression; Protein domain; Genetics; Repressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412463,0.0004917572,0.000177584,0.0002100963,0.0003426376,0.0002651919,0.0002016017,0.0002048217,0.001238563],"category_scores_gemma":[0.0001684372,0.0001371578,0.0002016384,0.0001629835,0.000503617,0.0001324652,0.0002171849,0.0003828645,0.0005797059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000826965,"about_ca_system_score_gemma":0.0005032274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001749276,"about_ca_topic_score_gemma":0.002768037,"domain_scores_codex":[0.9999015,0.000007170873,0.000004035598,0.00002950498,0.00003113676,0.00002657872],"domain_scores_gemma":[0.999882,0.00001859922,0.0000380354,0.00001011754,0.00001818574,0.00003300085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008046132,0.00001400535,0.0004607998,0.0000346422,0.000004201678,0.00005740541,0.00001023561,0.00009777952,0.996996,0.0002622224,0.00006873569,0.00191346],"study_design_scores_gemma":[0.00004061958,0.00008141829,0.02040293,0.00001566861,0.00001725047,0.0004609647,0.0000207908,0.002184052,0.9695801,0.0002267437,0.006959043,0.00001055808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897427,0.002129588,0.004849464,0.0001151749,0.00001982496,0.00002872261,0.0003505607,0.00007930341,0.002684645],"genre_scores_gemma":[0.992649,0.0006992231,0.003013817,0.00005219167,0.00001133804,0.00003259058,0.0009058907,0.00002437146,0.002611583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749276,"threshold_uncertainty_score":0.006000102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478833329397584,"score_gpt":0.2165177078157575,"score_spread":0.2017293745217817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}