{"id":"W2079329269","doi":"10.1021/jm1007853","title":"Interaction of Daunomycin with Acetylated Chromatin","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Acetylation; Chromatin; Nucleosome; Histone; Histone deacetylase; Bromodomain; DNA; Biochemistry; Biophysics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506006,0.0001588837,0.0002237364,0.0001342577,0.0002251818,0.0002842799,0.0001949224,0.0001840215,0.0009338835],"category_scores_gemma":[0.0002338012,0.0001195069,0.0001405142,0.0001250736,0.000176688,0.0001426454,0.0001973099,0.000372659,0.0002512371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003468667,"about_ca_system_score_gemma":0.0001398587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009286104,"about_ca_topic_score_gemma":0.001572904,"domain_scores_codex":[0.9998063,0.00004773915,0.000009973744,0.00005659808,0.00004794954,0.00003146684],"domain_scores_gemma":[0.9998487,0.00005828695,0.00002638629,0.00001932798,0.00001489664,0.00003243582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004320517,0.00001103499,0.0003097917,0.00001320068,0.000006011022,0.00001715526,0.00001644853,0.00005193503,0.998936,0.00007160947,0.00001326121,0.0005103534],"study_design_scores_gemma":[0.00000770018,0.0001071721,0.005758024,0.000004097987,0.000006159115,0.00008223784,0.00002026586,0.001343065,0.9910419,0.00003525788,0.00158872,0.000005376207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957908,0.0009789102,0.00199094,0.0000487274,0.00001601032,0.000009077881,0.00005557393,0.00002119069,0.001088764],"genre_scores_gemma":[0.996972,0.0003328454,0.001493969,0.00004753164,0.000006370753,0.00000613406,0.0001429677,0.00001007275,0.0009880617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009338835,"threshold_uncertainty_score":0.003124177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003322060541648438,"score_gpt":0.2242784381710347,"score_spread":0.2209563776293863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}