{"id":"W2079353397","doi":"10.1007/s12185-011-0766-2","title":"A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis","year":2011,"lang":"en","type":"article","venue":"International Journal of Hematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut national de la recherche scientifique","keywords":"Dasatinib; Imatinib; clone (Java method); Myeloid leukemia; Mutant; Mutation; Biology; Cancer research; Imatinib mesylate; breakpoint cluster region; Nilotinib; ABL; Molecular biology; Genetics; Virology; Tyrosine kinase; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008768484,0.0003724802,0.0003465284,0.0006766481,0.0004204131,0.000323988,0.0004432932,0.001012505,0.001313982],"category_scores_gemma":[0.0004872,0.0002160907,0.0003151423,0.000466835,0.0003932804,0.0002543855,0.0002673732,0.0005514664,0.0002921333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245553,"about_ca_system_score_gemma":0.0002192591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456726,"about_ca_topic_score_gemma":0.001433786,"domain_scores_codex":[0.9998658,0.00001026576,0.0000143,0.00003803736,0.00002373367,0.00004786138],"domain_scores_gemma":[0.9997686,0.00008064721,0.0000415892,0.00001081316,0.00001810201,0.00008025049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001330363,0.0002703708,0.1284459,0.0000591835,0.00004761855,0.662982,0.0005202531,0.0006693559,0.1966022,0.0004128053,0.0006184402,0.008041499],"study_design_scores_gemma":[0.0001173549,0.001148591,0.3534447,0.00001180334,0.0001412071,0.6068896,0.0003980037,0.003262573,0.03239641,0.0002649574,0.001889082,0.00003575028],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998709,0.00008087621,0.000215984,0.0001173999,0.000006890525,0.00001846897,0.0001681937,0.00001041866,0.0006727948],"genre_scores_gemma":[0.9993802,0.0000387357,0.0002093607,0.00005566532,0.00001101227,0.000003805086,0.0001038216,0.000004853792,0.0001925804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456726,"threshold_uncertainty_score":0.004395723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472036030377479,"score_gpt":0.2663464164310432,"score_spread":0.2516260561272685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}