{"id":"W2079355808","doi":"10.1016/j.jconrel.2010.01.031","title":"A top-down approach for construction of hybrid polymer-virus gene delivery vectors","year":2010,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Illinois at Urbana-Champaign; McMaster University; National Science Foundation","keywords":"Viral envelope; Polyethylenimine; Gene delivery; Murine leukemia virus; Retrovirus; Biology; Genetic enhancement; Transgene; Nucleic acid; Viral vector; Virology; Gene; Virus; Cell biology; Molecular biology; Chemistry; Transfection; Biochemistry; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006416388,0.0001577204,0.0004625908,0.0001653404,0.00006966286,0.00001960676,0.000259244,0.0001159836,0.00003717876],"category_scores_gemma":[0.0003163453,0.000125746,0.000417617,0.00007607158,0.0001504884,0.000008297046,0.00002972083,0.0002701137,9.83265e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000139858,"about_ca_system_score_gemma":0.000436181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009502737,"about_ca_topic_score_gemma":0.000009679506,"domain_scores_codex":[0.9986181,0.0001176577,0.0005669772,0.0001777965,0.0002752822,0.0002441937],"domain_scores_gemma":[0.9983976,0.00006086625,0.0005234387,0.0002810502,0.000557354,0.0001796172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03414694,0.0001896074,0.00009934742,0.00001828273,0.000352185,0.000008030624,0.000009229394,0.0001727139,0.9560037,0.0000200742,0.0004144842,0.008565411],"study_design_scores_gemma":[0.01301176,0.00328616,0.00002555424,0.00000588666,0.0001027397,0.0002401884,0.00002976544,0.0004730217,0.9814913,0.00005155829,0.001157051,0.0001250561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912112,0.002662688,0.005073476,0.0001116344,0.0003323134,0.0004269449,0.00004349381,0.000003435082,0.0001347525],"genre_scores_gemma":[0.9951531,0.0003818217,0.003387588,0.00009716894,0.0007367374,0.00002215651,0.00002002751,0.00002611612,0.0001752535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02548757,"threshold_uncertainty_score":0.5127773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007316951928381767,"score_gpt":0.2540093152044335,"score_spread":0.2466923632760518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}