{"id":"W2079372567","doi":"10.1073/pnas.1100567108","title":"CD4 <sup>+</sup> T cells support cytotoxic T lymphocyte priming by controlling lymph node input","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia","funders":"National Institutes of Health; Astellas Foundation for Research on Metabolic Disorders; National Institute of Allergy and Infectious Diseases; Astellas Pharma; American Heart Association","keywords":"Cytotoxic T cell; Priming (agriculture); CD40; Biology; CTL*; Antigen-presenting cell; Immune system; Lymph node; Immunology; Antigen; Interleukin 21; T lymphocyte; CD8; Cell biology; T cell; Molecular biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334142,0.0004820466,0.0002275292,0.0002642003,0.0001597805,0.000545365,0.000302396,0.0002890933,0.003667038],"category_scores_gemma":[0.000174685,0.0001347002,0.0001743755,0.0001281519,0.0002414097,0.000288305,0.0003154345,0.0005812589,0.002095488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029191,"about_ca_system_score_gemma":0.0002922921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002169077,"about_ca_topic_score_gemma":0.0003111443,"domain_scores_codex":[0.9998518,0.00002956582,0.00001077178,0.00001902871,0.00002642749,0.0000623259],"domain_scores_gemma":[0.9998355,0.00002178874,0.00002938543,0.00002857166,0.00002966399,0.0000550479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003092791,0.00006443303,0.0007998225,0.00009979335,0.000005867189,0.0001206615,0.00001304931,0.0003474451,0.9868513,0.0004842405,0.0004485143,0.01045559],"study_design_scores_gemma":[0.0000930158,0.0005784294,0.003451783,0.00001680846,0.00002937285,0.0005393185,0.0000663822,0.003392834,0.9747444,0.0006874372,0.01639214,0.000008220197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616708,0.004091354,0.0134185,0.0004864188,0.0002231188,0.0000994101,0.0006968352,0.0007571078,0.01855651],"genre_scores_gemma":[0.9816565,0.0009221689,0.01033865,0.0001644997,0.0001192037,0.0000463967,0.0007348452,0.00008315595,0.005934515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003667038,"threshold_uncertainty_score":0.01226741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03032433221394255,"score_gpt":0.2492644757474198,"score_spread":0.2189401435334772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}