{"id":"W2079384683","doi":"10.1002/art.11014","title":"In vivo selective inhibition of mitogen‐activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes","year":2003,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Osteoarthritis; Cartilage; Medicine; MAPK/ERK pathway; Kinase; Protein kinase A; Collagenase; Anterior cruciate ligament; Synovial membrane; Pathology; Arthritis; Internal medicine; Endocrinology; Chemistry; Surgery; Anatomy; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003940729,0.000295366,0.0006061186,0.0004500008,0.00007485771,0.00001484603,0.00006127137,0.0001645077,0.0001781747],"category_scores_gemma":[0.00009499933,0.000256024,0.00005510518,0.0008860675,0.0001228835,0.0002857559,0.00001911737,0.0002529004,0.000002051178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305677,"about_ca_system_score_gemma":0.0002094252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003594314,"about_ca_topic_score_gemma":0.007375309,"domain_scores_codex":[0.9977242,0.0003087144,0.0007049622,0.000388231,0.0004714763,0.0004024585],"domain_scores_gemma":[0.9992565,0.00004932561,0.0003061047,0.0002088101,0.0001152141,0.0000640658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004875868,0.0006727396,0.002340368,0.00004946236,0.00003378112,0.0001937489,0.03709872,0.000001900451,0.9335606,0.000450262,0.00001966059,0.02509123],"study_design_scores_gemma":[0.01581357,0.002737388,0.004376485,0.005535136,0.00001088249,0.0001670831,0.005718199,0.000003820831,0.9650372,0.0003467505,0.00001887433,0.0002345875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948141,0.002365411,0.000003287462,0.0001285136,0.00009562273,0.002249815,0.00003564133,0.00002096206,0.000286667],"genre_scores_gemma":[0.9980929,0.00006992088,0.00101384,0.00003774085,0.00000897719,0.0006213867,0.00006594509,0.00003260754,0.00005666016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03147668,"threshold_uncertainty_score":0.9999892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011584447809947,"score_gpt":0.2388385363280159,"score_spread":0.2272540885180689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}