{"id":"W2079392960","doi":"10.1016/j.bmcl.2008.12.075","title":"N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Trifluoromethyl; Pyrazole; Thiazole; Benzofuran; Stereochemistry; Pyridine; Chemical synthesis; Carboxamide; Isoindoline; Enzyme inhibitor; Lipophilicity; Enzyme; Biochemistry; Medicinal chemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002882668,0.0002950477,0.0003518514,0.0002482928,0.0001938275,0.0001628333,0.000643723,0.000317192,0.001535153],"category_scores_gemma":[0.0001872276,0.0001392553,0.0002044229,0.0001978493,0.0001804193,0.0002215931,0.0001916547,0.0004450584,0.0004385302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718715,"about_ca_system_score_gemma":0.000230295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052572,"about_ca_topic_score_gemma":0.002286785,"domain_scores_codex":[0.9998387,0.00003064764,0.000007980531,0.00002264665,0.00003124871,0.0000687752],"domain_scores_gemma":[0.9999417,0.00001181468,0.00001746689,0.000007343321,0.000007582545,0.00001398883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130837,0.0002517697,0.0004453981,0.0002368667,0.00003499333,0.0004408501,0.0001033143,0.00107978,0.9614193,0.001846562,0.001358757,0.03147409],"study_design_scores_gemma":[0.0006609238,0.004021481,0.005101255,0.0000279529,0.00008427557,0.001380722,0.00004537762,0.002957948,0.9652242,0.0001726102,0.02028423,0.00003897567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654339,0.01180199,0.006904985,0.0002830683,0.0002254021,0.0001245575,0.0003359291,0.0003803616,0.01450974],"genre_scores_gemma":[0.9915379,0.003315392,0.002019727,0.00007944725,0.0000406374,0.00006334111,0.000253634,0.00001770518,0.002672211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535153,"threshold_uncertainty_score":0.005135596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082196093115802,"score_gpt":0.2389423912286672,"score_spread":0.2281204302975092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}