{"id":"W2079402257","doi":"10.2165/00063030-200115050-00001","title":"C2 Monitoring Strategy for Optimising Cyclosporin Immunosuppression from the Neoral??* Formulation","year":2001,"lang":"en","type":"review","venue":"BioDrugs","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Immunosuppression; Medicine; Therapeutic drug monitoring; Nephrotoxicity; Trough level; Transplantation; Kidney transplantation; Urology; Ciclosporin; Pharmacology; Internal medicine; Drug; Kidney; Tacrolimus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548377,0.0003976188,0.001197011,0.00004920045,0.0003017905,0.00005969716,0.0001920394,0.0002989445,0.00004765042],"category_scores_gemma":[0.0001247811,0.0002049587,0.0005330081,0.0001974954,0.00004445257,0.00007625628,0.0001057538,0.0003940481,0.00002125799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510256,"about_ca_system_score_gemma":0.00008131467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008685273,"about_ca_topic_score_gemma":6.333186e-7,"domain_scores_codex":[0.9984723,0.00008731545,0.0004876614,0.0003847856,0.00022019,0.0003477049],"domain_scores_gemma":[0.9984027,0.0008477706,0.0002935636,0.0002981224,0.0000671996,0.00009062295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006291521,0.00006719216,0.0000383644,0.001777532,0.0002803494,0.00001333796,0.0000428656,0.000005570345,0.00006501059,0.00001699772,0.001412378,0.9962175],"study_design_scores_gemma":[0.0007276773,0.0001713976,0.0003074372,0.009287932,0.001670368,0.00001061994,0.00005662231,0.00007146966,0.0001135877,0.00008095541,0.9872467,0.000255224],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007223913,0.9955134,0.0001238374,0.0002069262,0.0006887214,0.002088272,0.00009911593,0.00009095393,0.0004664195],"genre_scores_gemma":[0.001650671,0.994686,0.0006273458,0.00006128812,0.002036908,0.0002045104,0.0002731669,0.00004331882,0.0004168094],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9959623,"threshold_uncertainty_score":0.8357974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2002765864096752,"score_gpt":0.4437927799303807,"score_spread":0.2435161935207055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}