{"id":"W2079421845","doi":"10.1371/journal.pone.0029336","title":"Intra- and Inter-Tumor Heterogeneity of BRAFV600EMutations in Primary and Metastatic Melanoma","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; York University; U.S. Department of Veterans Affairs","keywords":"Tumor heterogeneity; Metastatic melanoma; Melanoma; Primary (astronomy); Primary tumor; Medicine; Cancer research; Oncology; Metastasis; Biology; Pathology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172115,0.0000743036,0.0001479229,0.00003842729,0.00001695529,0.000005203765,0.00004039191,0.00003007724,0.000006256132],"category_scores_gemma":[0.0000481594,0.0000706585,0.00001561122,0.00003452439,0.00006006102,0.000006470275,0.00007124167,0.00004041252,0.00000153232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000471939,"about_ca_system_score_gemma":0.00001504529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008684834,"about_ca_topic_score_gemma":0.00002563352,"domain_scores_codex":[0.999499,0.00004367841,0.0001450909,0.0001235073,0.00005727282,0.0001314904],"domain_scores_gemma":[0.9997333,0.00001529945,0.00004776262,0.0001180864,0.00001981279,0.00006573637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002884769,0.0004166025,0.1391734,0.0001610634,0.00008479602,0.000001607425,0.0001280625,1.504656e-7,0.859197,0.0000854702,0.00001631073,0.000706654],"study_design_scores_gemma":[0.000552853,0.0002758018,0.1568751,0.00004440417,0.00007098123,0.00001815443,0.00005857071,0.00002461912,0.8417921,0.00007166915,0.0000929853,0.0001227228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977828,0.001376788,0.000159574,0.00003385431,0.00001538324,0.0001324196,0.00002407912,0.000003434306,0.0004716705],"genre_scores_gemma":[0.9970169,0.00008323684,0.002663048,0.0001037477,0.0000350679,0.0000170512,0.00004014112,0.000008356621,0.00003242439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01770171,"threshold_uncertainty_score":0.288137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978751268876376,"score_gpt":0.23192001735447,"score_spread":0.2021325046657062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}