{"id":"W2079423300","doi":"10.1021/bi200747f","title":"Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2′′-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source","keywords":"Aminoglycoside; Tobramycin; Kanamycin; Chemistry; Binding site; Antibiotics; Enzyme; Transferase; Phosphotransferases; Stereochemistry; Hydrolase; Substrate (aquarium); Biochemistry; Biology; Biophysics; Gentamicin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266659,0.0005453582,0.0007479399,0.0002360433,0.0005418574,0.001132878,0.0009613603,0.0007048394,0.001093393],"category_scores_gemma":[0.0005456713,0.0005085989,0.0003924793,0.0005869802,0.0003499121,0.0004915834,0.0003379651,0.00226835,0.0002079612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001431829,"about_ca_system_score_gemma":0.0007148164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007194067,"about_ca_topic_score_gemma":0.007524958,"domain_scores_codex":[0.9997811,0.00003339219,0.00001315852,0.0000496883,0.00008165749,0.00004106608],"domain_scores_gemma":[0.9997508,0.00008898955,0.00004761515,0.0000147287,0.00004797478,0.00004981124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002281738,0.001449403,0.03670684,0.001144013,0.0008870399,0.004176799,0.003101659,0.04036908,0.8520362,0.008119562,0.01492244,0.03480529],"study_design_scores_gemma":[0.001910892,0.001141396,0.2043176,0.0002758014,0.0008227951,0.005774478,0.003092142,0.2965349,0.414531,0.005259984,0.06597631,0.0003627051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929708,0.002331895,0.001700443,0.0003383926,0.00004519651,0.00001448767,0.0005630902,0.0001276082,0.00190815],"genre_scores_gemma":[0.9863105,0.001784442,0.006080862,0.000156815,0.00001980911,0.00004080677,0.003747536,0.00007987612,0.001779414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007194067,"threshold_uncertainty_score":0.0143044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02710908307241237,"score_gpt":0.2243930416162044,"score_spread":0.197283958543792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}