{"id":"W2079491315","doi":"10.1246/cl.2006.952","title":"Synthesis of Gemcitabine Analogues as Potential Anti-tumor Agents","year":2006,"lang":"en","type":"article","venue":"Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bausch Health (Canada)","funders":"","keywords":"Chemistry; Gemcitabine; Bicyclic molecule; Deoxycytidine; Combinatorial chemistry; Stereochemistry; Derivative (finance); Cytidine deaminase; Organic chemistry; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00003170815,0.0001182897,0.000242116,0.00002590665,0.00002587831,0.00000453935,0.00006356095,0.00003984919,0.001210096],"category_scores_gemma":[0.00001353983,0.000109637,0.0001160097,0.00008082074,0.00009845875,0.00002260058,0.00001828961,0.00007131586,0.00002632727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005556954,"about_ca_system_score_gemma":0.00002969559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551211,"about_ca_topic_score_gemma":7.122832e-7,"domain_scores_codex":[0.9993314,0.000007923585,0.0001747205,0.0001771343,0.0001335665,0.0001752341],"domain_scores_gemma":[0.9996655,0.00002409803,0.00007930448,0.0001491055,0.00002601845,0.00005597253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009328822,0.0001986094,0.01436377,0.0001548038,0.0001128145,0.0003504939,0.000009143311,0.00001887011,0.9581648,0.00000100379,0.02633877,0.0001936211],"study_design_scores_gemma":[0.001093206,0.00001754439,0.02887443,0.00003656964,0.0003202231,0.0001077332,0.00001263297,0.00001876242,0.9670505,0.00000723335,0.002368912,0.00009225462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919639,0.0001508889,0.000009682137,0.002956371,0.00009072704,0.00008440776,0.00002326555,0.00003233223,0.004688477],"genre_scores_gemma":[0.9978257,0.000015527,0.00007643728,0.0008620188,0.0004165505,0.00001584314,0.00009552945,0.00001382317,0.0006785261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02396986,"threshold_uncertainty_score":0.9997029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007690816572399848,"score_gpt":0.2572107700491941,"score_spread":0.2495199534767943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}