{"id":"W2079522835","doi":"10.1016/j.ijantimicag.2004.06.010","title":"Pharmacodynamic target attainment analysis against Streptococcus pneumoniae using levofloxacin 500mg, 750mg and 1000mg once daily in plasma (P) and epithelial lining fluid (ELF) of hospitalized patients with community acquired pneumonia (CAP)","year":2004,"lang":"en","type":"article","venue":"International Journal of Antimicrobial Agents","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Winnipeg; Health Sciences Centre; University Health Network; University of Toronto; University of Manitoba","funders":"Canadian Institutes of Health Research; University of Toronto; Canadian Thoracic Society","keywords":"Levofloxacin; Streptococcus pneumoniae; Medicine; Pharmacokinetics; Community-acquired pneumonia; Pharmacodynamics; Pneumonia; Internal medicine; Area under the curve; Cmax; Pharmacology; Antibiotics; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005042566,0.0004239609,0.001086669,0.0001989559,0.0001636631,0.0004204718,0.0002869468,0.0005479136,0.001152185],"category_scores_gemma":[0.001819054,0.0001947428,0.0007265363,0.0002450501,0.000223092,0.0004139985,0.0001756593,0.000900493,0.000168316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004850118,"about_ca_system_score_gemma":0.000335081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078496,"about_ca_topic_score_gemma":0.001315604,"domain_scores_codex":[0.9995416,0.0001905245,0.00003795076,0.00007571344,0.00006062433,0.0000935384],"domain_scores_gemma":[0.9994318,0.0002389899,0.0001163172,0.00002310438,0.00004434325,0.0001455426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6366534,0.008322309,0.05551775,0.0005325353,0.001181399,0.0009727306,0.0004502962,0.005384626,0.1437593,0.0002081597,0.001146429,0.1458712],"study_design_scores_gemma":[0.02930454,0.5440048,0.3628229,0.00004677313,0.002056,0.001401399,0.0003527328,0.01057534,0.04684291,0.0002343951,0.002268643,0.00008961775],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986939,0.000605622,0.0001662452,0.0000815407,0.00001206711,0.00003141702,0.00008535074,0.00001775822,0.0003062611],"genre_scores_gemma":[0.9994391,0.0001643867,0.000100874,0.00004814092,0.00001576926,0.00001674658,0.0000884749,0.000001919531,0.0001247679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152185,"threshold_uncertainty_score":0.003854454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304821590444717,"score_gpt":0.2824692215232312,"score_spread":0.2694210056187841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}