{"id":"W2079607047","doi":"10.1002/jgm.1329","title":"Stringent testing identifies highly potent and escape‐proof anti‐HIV short hairpin RNAs","year":2009,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw","keywords":"Computational biology; Human immunodeficiency virus (HIV); Burden of proof; Proof of concept; Biology; Virology; Computer science; Law; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001635344,0.0007428292,0.0004917026,0.0004133666,0.0002311846,0.0005839588,0.0004875054,0.0007784557,0.001582429],"category_scores_gemma":[0.001594542,0.0002600359,0.000392042,0.0002518933,0.0004592724,0.0004410105,0.0004283162,0.0005777524,0.000591234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481065,"about_ca_system_score_gemma":0.0003767988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002458659,"about_ca_topic_score_gemma":0.0008035562,"domain_scores_codex":[0.9981528,0.0004084789,0.0002138748,0.000294899,0.0007887137,0.0001413055],"domain_scores_gemma":[0.9981172,0.000719179,0.000317542,0.0001751411,0.0005140275,0.0001569543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005630287,0.0001157663,0.001212197,0.00004877233,0.00001090662,0.00004104097,0.00002018751,0.000273086,0.9952916,0.0000871183,0.0000722666,0.002770728],"study_design_scores_gemma":[0.00001259211,0.00127688,0.003489821,0.00000577992,0.00002602717,0.0002123392,0.00002108111,0.001435528,0.9920121,0.00005647857,0.001444802,0.00000665292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622082,0.001378125,0.03283188,0.0001272939,0.00004253661,0.0005985927,0.0005454283,0.0001767764,0.002091166],"genre_scores_gemma":[0.9619866,0.0006290738,0.03337854,0.000214873,0.00003209247,0.0003961753,0.001424735,0.00007725577,0.001860532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635344,"threshold_uncertainty_score":0.008648634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129167027768498,"score_gpt":0.2605466695276389,"score_spread":0.2392549992499539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}