{"id":"W2079622341","doi":"10.1016/j.ejmech.2011.05.054","title":"Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre; Dalhousie University; Izaak Walton Killam Health Centre; Acadia University","funders":"University of Delhi; KU Leuven; Dalhousie University; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Chemistry; Pharmacophore; Stereochemistry; Selective estrogen receptor modulator; Estrogen receptor; Enantiomer; Moiety; Alkoxy group; Molecular model; Combinatorial chemistry; Organic chemistry; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714765,0.000396801,0.0004608942,0.0002654524,0.0002262969,0.0003092634,0.0004179482,0.0002698229,0.00191235],"category_scores_gemma":[0.0002919732,0.0001926378,0.0002400935,0.0002206484,0.0001773132,0.0002770017,0.0002268484,0.0003745256,0.0003540082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003225509,"about_ca_system_score_gemma":0.0003737792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002907701,"about_ca_topic_score_gemma":0.001024425,"domain_scores_codex":[0.9998869,0.00002836694,0.000009958037,0.0000166282,0.00002815865,0.00002994101],"domain_scores_gemma":[0.9999362,0.00001196364,0.00001654989,0.000005945795,0.00001362023,0.0000157058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180878,0.0006367601,0.0005215803,0.0004966839,0.00006453683,0.000559833,0.0001344851,0.003404933,0.9462295,0.002384832,0.0007797616,0.04360625],"study_design_scores_gemma":[0.0007008595,0.00740053,0.0009909135,0.00003673129,0.0001398135,0.0005787294,0.00007366284,0.002092726,0.9656463,0.0003398653,0.0219759,0.000023994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9510029,0.01512466,0.0249522,0.0005137175,0.0001384973,0.000871824,0.000815829,0.000168926,0.006411431],"genre_scores_gemma":[0.955399,0.01381572,0.02155411,0.0002278736,0.00005005729,0.0004344031,0.001081577,0.00002591223,0.007411345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191235,"threshold_uncertainty_score":0.006397486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115567725202314,"score_gpt":0.2311381297853118,"score_spread":0.2099824525332887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}